卵巢癌是妇科常见的恶性肿瘤,死亡率居妇科之首。化疗是目前治疗卵巢癌的重要手段之一。化 疗耐药是影响卵巢癌病人生存率的主要原因。卵巢癌化疗耐药是多基因多因素共同参与的结果。近年来卵巢 癌化疗耐药相关基因成为监测预后的指标。本文从细胞内药物积聚减少、药物外排增加、药物失活增强;药物作 用的靶点异常;细胞凋亡调控的异常;对DNA 损伤的耐受性增加或损伤后的修复功能增强;细胞微环境的改变 这几方面对化疗耐药的研究进展作一综述。

Abstract:Ovarian cancer is a common gynecologic malignancy,and the mortality rate ranks first in the gynecological. Chemotherapy is one of the important means for the treatment of ovarian cancer. Re鄄 sistance to chemotherapy is the main impact of the survival rate of patients with ovarian cancer. Polygenic and multifactorial are resulted of the ovarian cancer resistance to chemotherapy. In recent years, associated genes which ovarian cancer resistance to chemotherapy become a indicators to monitor the prognosis of ovarian cancer. This article discussed the research progress of chemotherapy resistance from the following aspects, including the reduced intracellular drug accumulation、increased drug efflux、enhanced drug inactivation,the exception of drug targets,abnormal regulation of apoptosis, enhance the tolerance after the DNA damaged or strengthen the repair function it impaired, changed in cellular microenvironment

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