目的: 了解我院铜绿假单胞菌的感染分布与耐药情况，为临床治疗提供依据。方法: 对住院病人送
检样本中培养分离出的416 株铜绿假单胞菌的感染分布与耐药情况进行分析。采用稀释法进行药物敏感试验，
结果按美国临床实验室标准化研究所标准判定。结果: 铜绿假单胞菌主要分布在重症监护病房( ICU) 和呼吸
科，主要来自痰标本( 349 株83． 9%) ，对亚胺培南的耐药率最低( 15． 2%) ，其次为哌拉西林/他唑巴坦
( 22． 3%) ，对其他11 种抗菌药物的耐药率均较高。结论: 铜绿假单胞菌主要引起呼吸道感染，对现有多种抗菌
药物耐药严重，提示临床医师必须对该菌所致感染予以高度重视，关注易感人群，加强对该菌的监测，合理使用
抗菌药物，以提高疗效和减缓耐药菌株的产生^［1］。

Objective: To investigate the clinical distribution and drug resistance of Pseudomonas
aeruginosa and to offer basis for the clinical therapeutics． Methods: Analyze the infection distribution
and drug resistance of 416 samples of Pseudomonas aeruginosa that were isolated from various kinds of
specimens from inpatients． The drug sensitivity test was done by means of dilution，and the results were
assessed with Clinical and Laboratory Standards Institute． Results: Pseudomonas aeruginosa samples
were mainly distributed in intensive care unit( ICU) ward and Respiration department． The highest positive
rate of Pseudomonas aeruginosa was in sputum ( 83． 9%) ． The resistance rates to Imipenem
( 15． 2%) were the lowest． and to Piperacillin /Tazobactam( 22． 3%) came to be next． Pseudomonas
aeruginosa were high resistant to other 11 tested antibiotics． Conclusions Pseudomonas aeruginosa is a
common pathogen of respiratory tract infection，which has a high resistance rate to the current clinical
antibacterial agents． Consequently，clinical doctors should consider the infection results from Pseudomonas
aeruginosa to increase the positive effect and reduce drug resistance rate．

R37