目的: 了解粪肠球菌和屎肠球菌对抗菌药物的耐药性，为临床提供治疗依据。方法: 对住院及门诊
病人送检样本中培养分离出316 株肠球菌( 粪肠球菌126 株，屎肠球菌190 株) 的感染分布与耐药情况进行分
析。采用稀释法进行药物敏感试验，结果按美国临床实验室标准化研究所标准判定。结果: 屎肠球菌对青霉素
G 的耐药率最高( 93． 7%) ，其次为红霉素、氨苄西林和环丙沙星。粪肠球菌对奎奴普丁/达福普汀耐药率最高为
( 74%) ，其次为四环素、红霉素和环丙沙星。粪肠球菌和屎肠球菌对利奈唑胺和万古霉素的耐药率均低于
( 2%) ，替考拉宁的耐药率最低均为( 0) 。结论: 粪肠球菌和屎肠球菌对不同抗菌药物的耐药率有较大差异，在
抗感染治疗前应先做细菌培养和药物敏感试验，依据报告结果合理选用抗菌药物。

Objective: To get knowledge of antimicrobial resistance of Enterococcus Faecalis and
Enterococcus Faecium to antibiotics，and further provide basis for treatment． Methods: 316 strians of
enterococci composed of 126 strains of enterococcus faecalis and 190 strains of enterococcus faecium
were cultured and isolated from samples of inpatients and outpatients，and distribution of infection and
antimicrobial resistance were analyzed． Agar dilution method was used to do antibiotic susceptibility
test，a nd the results were determined based on the standard of Clinical and Laboratory Standard Institute
( CLSI 2012) ． Results: The resistance rate of enterococcus faecium to penicillin G( 93． 7%) is the
highest among all of the antimicrobial tested， followed by erythromycin，ampicillin，ciprofloxacin． The
resistance rate of enterococcus faecium to quinupristin /dalfopristin( 74%) was the highest among all of
the antimicrobials tested， followed by tetracycline，erythromycin and ciprofloxacin． The resistance rate of
enterococcus faecalis and enterococcus faecium to linezolid and vancomycin were all lower than 2%，
and that to teicoplanin was the lowest( 0%) ． Conclusions: The resistance rate of enterococcus faecalis
and enterococcus faecium to different kinds of antibiotics differed much． Bacterial culture and antimicrobial
susceptibility tests should be performed before anti－infection treatment initiated and reasonable
antibiotics be selected based on antimicrobial susceptibility test report．

R446． 13

 收稿日期: 2013－08－28; 修回日期: 2013－11－20
基金项目: 内蒙古自治区卫生厅医疗卫生科研计划项目( 2010102)
作者简介: 燕成岭( 1962－) ，男，内蒙古自治区人民医院检验科主任检验师。
通讯作者: 樊淑珍，主任检验师，E－mail: nmyyycl@126． com 内蒙古医科大学附属医院检验科， 010050