目的: 对血清CA125 检测联合PET/CT 显像在诊断早期卵巢癌中的应用于临床价值进行分析和探
讨。方法: 取卵巢病变病人110 例为本次研究对象，对其实施血清CA125 检测联合全身¹⁸F－FDG PET/CT 显像。
结果: 在本组病人中，70 例为卵巢癌，剩余40 例属良性病变。在血清CA125 指数水平方面，卵巢良性病变病人
与卵巢癌病人之间存在显著差异( P＜0． 05) ; 而卵巢良性病变病人与卵巢癌病人在SUV 最大值( SUV_max
) 方面同样存在显著差异( P ＜0． 05) ; 在早期诊断卵巢癌过程中，¹⁸F － FDG PET/CT 显像灵敏度为95． 1%，特异性
为79． 09%，阴性与阳性预测值分别为88． 5% 和93． 1%，准确性为80． 9%; 在卵巢癌早期诊断效能方面，¹⁸FFDG
PETCT 显像在上述指标方面均高于血清CA125 检测，但¹⁸F－FDG PET/CT 显像与CA125 检测联合可有效提
高前者诊断准确性( 88． 3%) 以及特异性( 91． 0%) 。结论: 在早期诊断卵巢癌过程中，¹⁸F－FDG PET/CT 显像具
有相对特异性以及高灵敏度，联合¹⁸F－FDG PET/CT 显像与血清CA125 检测有利于早期诊断卵巢癌准确性与特
异性的提高。

Abstract: Objective: To analyze and discuss the application and clinical value of serum CA125
detection combined with PET /CT imaging in the diagnosis of early ovarian cancer． Methods: A total of
110 patients with ovarian lesions were taken as the subjects，who received serum CA125 detection combined
with systemic ¹⁸F－FDG PET /CT imaging． Results: Among the patients，70 were ovarian cancer
and the rest 40 were benign lesions． Patients with benign ovarian lesions and those with ovarian cancer
showed significant difference( P＜0． 05) in both the serum CA125 level and SUV_max ． In the early diagnosis
of ovarian cancer， the sensitivity of ¹⁸F －FDG PET /CT imaging was 95． 1%， the specificity was
79． 09%， the negative and positive predictive values were 88． 5%and 93． 1%，and the accuracy was
80． 9%． As for the early diagnostic efficiency of ovarian cancer， the above indicators of ¹⁸F－FDG PET /
CT imaging were all higher than those of serum CA125 detection，but the combination of ¹⁸F －FDG
PET /CT imaging and CA125 detection can effectively improve the diagnostic accuracy of the former by
88． 3%and the specificity by 91． 0%． Conclusion: In the early diagnosis of ovarian cancer，¹⁸F－FDG
PET /CT imaging has relative specificity and high sensitivity． The combination of ¹⁸F－FDG PET /CT
imaging and serum CA125 detection can help to improve the accuracy and specificity of early ovarian
cancer diagnosis．

R711． 75

 收稿日期: 2013－11－14; 修回日期: 2014－01－12
基金项目: 国家自然科学基金( 81060019)
作者简介: 杜立平( 1974－) ，女，内蒙古医科大学附属医院核医学科主管技师。