目的:探讨草乌甲素滴丸中草乌甲素的溶出度。方法: 选用小杯法，以0． 1mol /L 盐酸为溶出介质，
转速为50 r /min，用高效液相色谱法测定草乌甲素的溶出度，绘制溶出曲线，计算溶出参数T50、Td、m，并用相似
因子法进行评价。结果:草乌甲素的检测浓度在3． 25 ～ 120μg /mL( r = 0． 9998) 范围内与其峰面积积分值呈良好
的线性关系;草乌甲素的平均回收率为99． 15%( RSD = 2． 27%) ，3 批样品溶出度相似。结论:本方法简便、准确、
可靠，可用于测定草乌甲素滴丸中主要组分的溶出度。

Objective: To determine the dissolution rates of Bulleyaconitine A in Bulleyaconitine A
dropping pills． Methods: The small glass cup method was adopted in which 0． 1mol /L hydrochloric
acid was taken as solvent with a rotating speed of 50 r /min． The dissolution rates of Bulleyaconitine A
were determined by HPLC． The dissolution curves were drawn，and the dissolution parameters including
T50，Td，and m were computed and evaluated using similar factors method． Results: The Bulleyaconitine
A were linear over the range of 3． 25 ～ 120μg /mL ( r = 0． 9998) ． The average recoveries of the ingredients
were 99． 15%( RSD = 2． 27%) ． The three batches samples were proved to be of similar dissolution
rates． Conclusion: The determination method is simple，accurate and reliable，which can be applied to
determine the dissolution rates of Bulleyaconitine A in Bulleyaconitine A dropping pills．

R94

 收稿日期: 2013 － 11 － 09; 修回日期: 2014 － 01 － 05
基金项目: 内蒙古自治区科技计划( 社发) 项目( 2011)
作者简介: 郭慧玲( 1969 － ) ，女，内蒙古医科大学药剂部主管药师。
通讯作者: 额尔德木图，E － mail: eerde_2006@ aliyun． com 内蒙古医科大学， 010059