[关键词]
[摘要]
特异性环氧化酶2(Cyclooxygenase - 2,COX - 2)抑制剂为COX - 2 的高选择性抑制物,是一类非甾
体抗炎药,具有抗炎镇痛作用,可以改善风湿性疾病的炎性症状并可缓解疼痛。近年来研究发现,特异性COX -
2 抑制剂会增加心血管疾病的发生率,在心肌肥厚中的作用也受到广泛关注。因此本文对特异性COX - 2 抑制
剂在心肌肥厚中作用作一综述。
[Key word]
[Abstract]
Cyclooxygenase 2(Cyclooxygenase - 2,COX - 2) inhibitor is highly selective COX - 2
inhibitors and a kind of non - steroidal anti - inflammatory drugs. This kind of drugs can reduce inflammation,
ease pain and improve the symptoms of Rheumatic diseases. Recent studies have found that
COX - 2 inhibitors may increase the rate of cardiovascular disease,thus the influence of these drugs on
cardiac hypertrophy has also been paid wide spread attention. Therefore in this article we have a review
to explore the role of COX - 2 inhibitors in cardiac hypertrophy.
[中图分类号]
R33
[基金项目]
收稿日期:2013 - 12 - 21;修回日期:2014 - 04 - 20
基金项目:内蒙古自治区自然科学基金(2012MS1152)
作者简介:司明明(1989 - ),女,内蒙古医科大学2011 级在读硕士研究生。
通讯作者:薛明明,硕士研究生导师,教授,E - Mail:happybird - nmg@ 163. com 内蒙古医科大学基础医学院,010059