目的: 研究兔脊柱融合术后邻近椎间盘软骨终板组织结构和形态学改变。方法: 54 只体重相当的
12 月龄日本大耳兔随机等分为2 组，一组为实验组，使用椎弓根螺钉和钢丝内固定的方法融合L 5 /6 节段，另一
组作为对照组，仅做相同部位皮肤切口后缝合。分别于术后3、6、9mo 每组取8 只动物处死并取出L 2 /3、L 4 /5
及L 6 /7 软骨终板进行HE 染色及Markin 评分。结果: 融合术后3、6 及9mo 时实验组L 4 /5、L 6 /7( 邻近节段)
软骨终板Mankin 评分较对照组高，差异有统计学意义( P＜0． 05) 。实验组L 4 /5( 融合平面以上邻近节段) 与L
6 /7( 融合平面以下邻近节段) 软骨终板Mankin 评分6、9mo 时较对照组高，差异有统计学意义( P＜0． 05) 。结论:
脊柱融合内固定术后邻近节段软骨终板较未融合固定者易发生退变，并且融合平面以上邻近节段较融合平面以
下邻近节段更易发生退变。

Objective: To study the structure and morphous of the adjacent cartilage endplate in
rabbits after spinal fusion． Methods: Totally 54 twelve－month old Japanese rabbits were randomly divided
into two groups． Each group included 27 rabbits． One group was experimental group，another one
was control group． L 5 /6 of all the experimental rabbits was surgery fused using screws and steel． The
control group model was incised only the skin． 8 rabbits of each group were killed at three， six and nine
months． After death，L 2 /3，L 4 /5 and L 6 /7 spines were harvested． All the exemplar hematoxylin and
eosin stain were performed． Results: Markin score of adjacent segment( L 4 /5 and L 6 /7) in experimental
group were higher than that in control group( P＜0． 05) ． The differences of Markin score between L
4 /5( the adjacent segment above the fusion level) and L 6 /7 ( the adjacent segment below the fusion
level) in the experimental group were statistically significant at 6month and 9month after spinal fusion
( P＜0． 05) ． Conclusion: The cartilage endplate of adjacent segment were easier to degenerate after spi-
nal fusion，and adjacent segment above the fusion level was easier to degenerate than that below the fusion
level．

R681． 5

 收稿日期: 2014－04－20; 修回日期: 2014－06－20
基金项目: 内蒙古卫生厅2010 年医疗卫生科研计划项目( 2010044)
作者简介: 贾海生( 1982－) ，男，蒙古族，内蒙古医科大学第二附属医院创伤科医师。
通讯作者: 杨学军，主任医师，教授，硕士研究生导师，E－mail: jiahaisheng0013@ 163． com 内蒙古医科大学第二附属医
院脊柱外科， 010030