目的: 建立测定槐定碱滴丸中槐定碱溶出度的方法。方法: 选用小杯法，以0． 1mol /L 盐酸为溶出介
质，转速为50 r·min^－1 ，用高效液相色谱法测定槐定碱的溶出度，绘制溶出曲线，计算溶出参数T₅₀、T_d、m，并用相
似因子法进行评价。结果: 槐定碱的检测浓度在6． 25 ～ 100μg·mL^－1( r = 0． 9997) 范围内与其峰面积积分值呈良
好的线性关系; 槐定碱的平均回收率为98． 23% ( RSD = 2． 17%) ，3 批样品溶出度相似。结论: 本方法简便、准
确、可靠，可用于测定槐定碱滴丸中主要组分的溶出度。

Objective: To determine the dissolution rates of Sophoridine in Sophoridine dropping
pills． Methods: The smal 1 glass cup method was adopted in which 0． 1mol /Lhydrochloric acid was
taken as solvent with a rotating speed of 50 r·min－1 ． The dissolution rates of Sophoridine were determined
by RP－HPLC． The dissolution curves were drawn，and the dissolution parameters including T50，
Td，and m were computed and evaluated using similar factors method.Results: The Sophoridine were
linear over the range of 6． 25 ～ 100μg·mL－1( r = 0． 9997) ． The average recoveries of the ingredients
were 98． 23%( RSD = 2． 17%) ． The three batches samples were proved to be of similar dissolution
rates． Conclusion: The determination method is simple，accurate and reliable，which can be applied to
determine the dissolution rates of Sophoridine in Sophoridine dropping pills simultaneously．

R917

 收稿日期: 2014－03－19; 修回日期: 2014－06－08
基金项目: 国家自然科学基金( 81260269) ; 内蒙古自然科学基金( 2012MS1149)
作者简介: 张兰( 1962－) ，男，内蒙古医科大学第一附属医院药剂科副主任药师。
通讯作者: 刘乐乐，教授，硕士研究生导师E－mail: liulele8821@ sina． com 内蒙古医科大学药学院， 010110