目的: 探讨血管内皮生长因子( Vascular Endothelial Growth Factor，VEGF) 在胶质瘤发病中的表达及
作用。方法: 用免疫组织化学染色的方法检测VEGF 表达蛋白在85 例不同病理分级( I 级、II 级、III 级和IV 级)
的胶质瘤及8 例正常脑组织中的表达情况。并结合细胞学观察进行胶质瘤相关性的分析研究。结果: VEGF 在
正常脑组织中均呈现弱阳性; 在85 例胶质瘤中，VEGF 阳性表达率为91． 17%，不同病理级别( I 级、II 级、III 级和
IV 级) 胶质瘤中VEGF 的表达不同，并随肿瘤级别的升高，其表达也明显升高，且各组间差异有统计学意义( P
＜0． 05) 。结论: VEGF 的表达强度随胶质瘤恶性程度的增加而增加，在不同级别脑胶质瘤的阳性表达之间有一
定的相关性，可以为临床预后评价及靶向治疗提供依据。

Objective: To investigate the expression and role of VEGF in the etiology of gliomas．
Methods: 85 cases with glioma of different Pathological grades ( GradeⅠ，Grade Ⅱ，Grade Ⅲ and
Grade Ⅳ) were took as the experimental group，8 cases of normal brain tissue were took as the normal．
Protein expression of VEGF in all cases were detected with the method of immunohistochemical staining．
Cytological observation were used to analyze the correlation between VEGF and Glioma． Ｒesult:
VEGF in normal brain tissues turn out to be weakly positive，and the positive expression rate of VEGF
in Glioma was 91． 17%． The rate differs with the different pathological grades( GradeⅠ，Grade Ⅱ，
Grade Ⅲ and Grade Ⅳ) and it’s expressions increases as the grade gets up; and the difference between
different groups has the statistics significance ( P ＜0． 05 ) ． Conclusion: The expression of VEGF
increased with the increase of glioma malignant degree of intensity，at different levels of brain glioma
has certain correlation between positive expression，can provide the basis for clinical prognosis
evaluation and targeted therapy．

Ｒ735． 2

 收稿日期: 2014－06－17; 修回日期: 2014－06－19
基金项目: 内蒙古自然科学基金项目( Kjt122rms108)
作者简介: 王睿君( 1980－) ，男，内蒙古医科大学附属医院放射线科住院医师，医学博士。