亲环素家族最先被认为是环胞素A( Cyclosporine A，CsA) 的胞内结合蛋白，在进化上有高度的保守
性，广泛表达于原核生物和真核生物中，在人体内有七个主要的亚型。亲环素A( cyclophilin A，CyPA) 作为亲环
素家族中最重要的一员，在自然界中广泛表达，发挥着肽基脯氨酰顺反异构( peptidylprolyl cistrans isomeras，PPIase)
活性和分子伴侣效应，辅助细胞内蛋白质的正确折叠，参与免疫抑制，介导炎性反应，平衡细胞内外胆固醇。
CyPA 在许多恶性肿瘤中均表达增高，在某些恶性肿瘤中，CyPA 的表达增高与肿瘤的恶性转化密切相关。而且
CyPA 直接受信号通路中与促进肿瘤发展密切相关的两个关键调控因子: p 53 与缺氧诱导因子－1α 的调控。本
文详细描述了亲环素家族，尤其是CyPA 的异常高表达对恶性肿瘤形成、发展的重要作用。这些特征表明，CyPA
是一个潜在的恶性肿瘤靶向治疗的靶点。

CyPs were identified as the intracellular receptors for the immunosuppressive drug cyclosporinA．
CyPs are found in all prokaryotes and eukaryotes，and have been structurally conserved
throughout evolution，implying their importance in cellular function． CyPA is the most important
member of Cyclophilins． It is a widely expressed protein in nature possessing PPIase and chaperone activities
which help the precise folding of protein． Also，it is involved in immunosuppression，
inflammation and the balance of cholesterol． Originally，CyPA is up－regulated in many human cancers，
and there is a strong correlation between over－expression of the CyPA gene and malignant transformation
in some cancers． Moreover，CyPA is directly under the transcriptional control of two critical transcription
factors for cancer development: p53 and hypoxia inducible factor－1a． This review discusses
the importance and diverse roles of overexpression of CyPA genes． These oncogenic properties suggest
that CyPA is a promising target for cancer therapy．

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 收稿日期: 2014－06－25; 修回日期: 2014－08－26
基金项目: 内蒙古科技厅重大科研项目( 20100501)
作者简介: 孙嘉阳( 1981－) ，男，内蒙古医科大学附属医院胸外科主治医师。