目的:探讨急性胰腺炎时Oddi 括约肌( SO) 生长抑素( SST) 的表达及其作用。方法: 采用逆行胰
胆管牛磺胆酸钠注射造成豚鼠急性胰腺炎动物模型，随机分为正常对照组、急性胰腺炎模型组和生长抑素预防
性治疗组。观察三组胰腺组织及SO 组织病理学改变和外周血淀粉酶及脂肪酶水平; 免疫组化检测三组SO 内
SST 的表达情况。结果: 急性胰腺炎豚鼠均见整个胰腺肿大，质软，部分肿大胰腺散在有黄白色脂肪坏死灶。镜
下见广泛细胞变性，间质水肿，炎性细胞浸润。部分伴广泛腺泡细胞及胰岛细胞坏死，腺体内片状间质出血斑;
生长抑素预防性治疗的急性胰腺炎豚鼠胰腺病理组织学较AP 时组织水肿减轻，细胞变性和坏死明显减少，评
分明显低于急性胰腺炎组，P＜0． 05。急性胰腺炎时SO 内SST 的表达减少。结论: 急性胰腺炎的发生静脉给予
SST，维持了豚鼠急性胰腺炎后循环中的SST 水平，SO 内SST 神经分泌明显减少，显著防止了胰腺炎症病变。

Objective: To investigate the expression of somatostatin and its receptor of sphincter of
Oddi( SO) in acute pancreatitis( AP) ． Methods: Guinea pigs were randomly divided into three groups，
the control group( N group，n = 6) ，acute pancreatitis model group( M group，n = 6) and somatostatin
treatment group( S group，n = 6) ． Pancreatitis induced by Tc－Na was confirmed by pancreatic histology
and serous levels of amylase and lipase． Somatostatin( SST) and its receptors( SSTＲs) in SO were visualized
by immunohistochemistry． SST level in plasma was determined by radioimmunoassay． Ｒesults:
The inflammatory scores of the pancreas and serous levels of amylase or lipase in the macaques that underwent
AP were significantly higher than those in the control group，P＜0． 05． Compared with control，
SST innervation and SSTＲ 2 expression in SO of guinea pigs treated with AP were greatly increased，P
＜0． 05． Changes due to AP could be markedly alleviated by prophylactic infusion of SST before AP，P
＜0． 05． Conclusions: ． Prophylactic infusion of SST at the plasma concentration close to the control
group efficiently avoided the increased SST innervation in SO during AP，and it might be helpful to ameliorate
pancreatitis

Ｒ57

 收稿日期:2014－09－20; 修回日期:2014－11－01
基金项目:内蒙古教育厅重大项目( NJZZ11114)
作者简介:徐赫一( 1990－) ，女，蒙古族，内蒙古医科大学2013 级在读硕士研究生。
通讯作者:陈平，主任医师，硕士研究生导师E－mail: nmgcp@ sina． com 内蒙古医科大学附属医院消化内科， 010050