骨转移是许多恶性肿瘤常见的转移形式，骨转移的诊断对于恶性肿瘤的分期、治疗和预后判断有者
极其重要的意义。目前骨转移主要诊断方法是注射鍀标记亚甲基二膦酸盐( 99 mTc－MDP) SPECT 闪烁骨显像
( bone imaging) ，骨显像是肺癌、乳腺癌和前列腺癌术前及复查的常规评价手段。99 mTc－MDP 骨显像是通过骨盐
代谢活性的改变间接反应骨转移，由于骨显像灵敏度较高特异性相对较低的问题对于骨骼良性病变增加了假阳
性的可能性;另外在核医学科99MO－99 mTc 发生器的供应是获得99 mTc－MDP 的唯一途径，由于途径单一且受多种
因素影响常出现断货现象，影响骨显像的正常进行。近年来探讨骨显像的多种检查手段( SPECT、18F－NaF PETCT)
运用成为关注点，经过对比研究探讨18F－氟化钠PET－CT 骨显像的应用作为解决上述问题措施的优势。

Osseous metastasis is the common spread pattern of many malignant tumors and
diagnosis of osseous metastasis profoundly impacts the staging， treatment and prognosis of malignant
tumors． 99 mTc－MDP SPECT bone imaging is the main diagnostic method nowadays and the routine
measurement for pre－operation and reexamination of lung canter，breast cancer and prostate cancer． 99
mTc－MDP SPECT bone imaging reflects osseous metastasis indirectly through the change of bone metabolic
activity and the false positive results of benign lesions may also arise due to the high sensitivity
and relatively low specificity of bone imaging． Besides， the only way to obtain 99 mTc－MDP in nuclear
medicine department is purchasing 99 MO－99 mTc generators，which is single and affected by multifactors
resulting in out of stock and affecting the normal process of bone imaging． Ｒecently，experts
focus on the application of multiple inspective items( such as SPECT，18 F－FDG PET－CT and 18 F－
NaF PET－CT) in bone imaging． By comparison and study，here we discuss the advantages of 18 F－NaF
PET－CT in bone imaging and consider it as a solution for problems above． out of stock and affecting the
normal process of bone inspective items( such as SPECT，18F－FDG PET－CT and 18F－NaF PET－CT) in
bone imaging． imaging． Ｒecently，nuclear medicine departments possessing generators focus on the application
of multiple Here we discuss the advantages of 18F－NaF PET－CT in bone imaging and consider
it as a solution for problems above．

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 收稿日期:2014－09－25; 修回日期:2014－11－01
基金项目:国家自然科学基金( 81260224)
作者简介:张凯秀( 1965－) ，女，内蒙古医科大学附属医院核医学PET/CT 副主任医师。
通讯作者:王雪梅，主任医师，E－mail: wangxuemei201010@163． com 内蒙古医科大学附属医院核医学PET/CT， 010050