乳腺癌分子靶向治疗已经成为继手术、放疗和化疗传统治疗模式之后的一种全新治疗手段。乳腺
癌分子靶向治疗是指乳腺癌发生、发展有关的癌基因及其相关表达产物进行的治疗，是通过对细胞增殖、细胞凋
亡、信号传导通路和新生血管形成等多个靶点作用于肿瘤细胞，其特异性较强，毒副反应相对小。在约20% ～
25%的乳腺癌的癌组织中有HER － 2 受体基因的过度表达。因此，HER － 2 成为乳腺癌靶向治疗的理想靶点。

Molecular targeted therapy is a novel technique for breast cancer． The main mechanisms
of the technique target numerous genes for cancer development，which suppress cancer cell proliferation，
enhance tumor apoptosis，block signal transduction pathway for amplified proliferation and decrease
angiogenesis etc． The advantages of the therapy are higher specific against tumor cells and less
side effects compared to common cytotoxic chemotherapy． Over expression of human epidermal growth
factor occurs in approximately 20% ～ 25% of breast cancers． Therefore，HER － 2 is a ideal target for
targeted therapy of breast cancer．

R737． 9