目的: 观察免疫三氧自血疗法治疗寻常型银屑病病人外周血血管内皮细胞生长因子( VEGF) 和缺氧
诱导因子－1α( HIF－1α) 水平变化，探讨免疫三氧自血疗法治疗银屑病的作用机制。方法: 选择我院70 例寻常
型银屑病病人，随机分为两组，即治疗组( 接受免疫三氧自血疗法) 病人35 例，对照组( 口服复方青黛丸) 病人35
例，两组病人接受治疗时间均为8wk。此外，取32 名健康志愿者作为空白对照。观察两组病人治疗前后的银屑
病面积，并计算两组病人严重程度指数( PASI) 评分，同时采用酶联免疫吸附法检测两组病人治疗前后外周血
VEGF 和HIF－1α 变化，并与治疗前后两组相应的PASI 评分作相关性分析。结果: 1．治疗组病人治疗前外周血
VEGF 和HIF－1α 含量明显高于正常人; 两组病人治疗后PASI 积分( 与治疗前相比) 明显下降，治疗组PASI 积
分下降水平( 与对照组相比) 更明显，治疗组总有效率为88．57%，对照组总有效率为57．14%，治疗组疗效优于对
照组; 治疗后两组外周血VEGF 和HIF－1α 浓度均下降，但治疗组( 与对照组相比) 下降水平更明显; 寻常型银屑
病病人皮损程度( 即PASI 积分) 与外周血VEGF 和HIF－1α 浓度呈正相关，VEGF 和HIF－1α 二者无明显相关
性。结论: 免疫三氧自血疗法治疗寻常型银屑病安全，疗效确切; 寻常型银屑病病人外周血中VEGF 和HIF－1α
浓度异常增高，免疫三氧自血疗法可以降低血中VEGF 和HIF－1α 的浓度，纠正异常表达的VEGF 和HIF－1α 水
平，从而达到治疗银屑病的目的。

Objective: This project aims to observe the change of medical ozone on psoriasis
vulgaris and its impact on VEGF and HIF－1α in serum and try to discorver the possible mechanism of
medical ozone in treating psoriasis vulgaris． Methods: 70 patients with psoriasis vulgaris were assigned
to join this study and were equally divided into the treatment group( medical ozone) and the control
group( Compound indigo naturalis pills) ．The period of treatment was 8 weeks．Besides，a normal control
group including 20 healthy volunteers was set up．This project respectively observed the PASI in the
treatment group and the control group，adopted the enzyme linked immunosorbent assay to test the
before and after treatment of these two groups on the contents change of peripheral blood，and did the
related analysis according to corresponding score．Results: The PASI scores were significantly decreased
after treatment in both groups，but the decrement in treatment group was more significant than that in
control group．The total clinical effective rates in treatment group was 88．57%，while control group were
57．14%; therefore， therapeutic effect in treatment group is superior to that in control group．The level of
VEGF and HIF－1α in serum in two groups before treatment was obviously higher than those in the
healthy control．After treatment， the levels of VEGF and HIF－1α in serum were significantly decreased
in both groups，and the changes in treatment group were more significant than those in control group．
There was a positive correlation between the level of VEGF or HIF－1α and PASI scores of psoriatic patients，
but there was not a correlation between VEGF and HIF－1α．Conclusion: Medical ozone is effective
and safe in the treatment of psoriatic vulgaris，and when VEGF and HIF－1α in peripheral blood of
psoriatic patients．are abnoemal，medical ozone can correct abnormal VEGF and HIF－1α， so as to achieve
a therapeutic effect．

R758．63