目的: 对内蒙古牧区蒙古族细菌性阴道病( Bacterial Vaginosis，BV) 病人和健康妇女阴道内乳杆菌及
局部分泌型免疫球蛋白A( secretary immunoglobulin A，SIgA) 含量进行研究，探讨蒙古族妇女阴道内乳杆菌与生
殖道免疫状况的相关性，为阴道微生态平衡与阴道黏膜免疫屏障关系的研究提供理论依据，并进一步丰富民族
地区阴道微生态理论。方法: 选取2014 － 03 ～ 2015 － 03 间45 名蒙古族健康妇女、37 名蒙古族BV 病人，采集阴
道分泌物行乳杆菌的分离、培养、鉴定、产H₂O₂能力检测，联合放射免疫双抗体夹心法测定阴道分泌液中SIgA
含量。结果: 蒙古族健康妇女阴道内乳杆菌检出率及产H₂O₂乳杆菌分离率明显高于BV 病人( P ＜ 0． 05) ，两组
主要菌种分布无统计学差异( P ＞ 0． 05) ，BV 病人阴道内局部SIgA 含量明显高于健康妇女( P ＜ 0． 05) 。结论:
H₂O₂阳性乳杆菌是健康妇女阴道内的重要成员，BV 病人阴道内乳杆菌数量、产H₂O₂能力及局部免疫功能发生
显著改变，乳杆菌对生殖道黏膜免疫状况具有调节作用，而生殖道免疫因子变化也会对阴道菌群有影响作用。

Objective: Study on Lactobacillus and SIgA Content between the women of mongol nationality
with bacterial vaginosis and healthy women of mongol nationality in Inner Mongolia pasture，To
investigate the relationship of Vaginal Lactobacillus and reproductive immunity in the Mongolian
women; provide theoretical foundation for studying the relationship between vaginal microecological balance
and vaginal mucosal immune barrier; and further enrich the theory of vaginal microecological in
ethnic minority areas． Methods: 45 Mongolian healthy women and 37 Patients of mongol nationality
with bacterial vaginosis were selected during March 2014 to March 2015． The vaginal secretions were
collected to isolation，culture， identification and detect the ability to product H₂O₂ of Lactobacillus;
Combined radioimmunoassay double antibody sandwich method to detect the SIgA content in vaginal secretions．
Results: The detection rates of Lactobacillus and ability to product H₂O₂ in the vaginas of
Mongulia healthy women were significantly higher than patients with bacterial vaginosis( P ＜ 0． 05) ，
There was no significant difference in distribution of major lactobacillus species between the two groups
( P ＞ 0． 05) ． The SIgA Content in the vagina of patients with bacterial vaginosis was significantly higher
than healthy women( P ＜ 0． 05) ． Conclusion: H₂O₂ － positive Lactobacillus is the important member in
healthy women vagina． The number，ability to product H₂O₂ and Local immune function of Lactobacillus
in patients with bacterial vaginosis have Changed significantly． Lactobacillus can regulate the immune
status of the reproductive tract mucosal，while changes in the reproductive tract immune factors also affect
the vaginal flora．

R711． 3

 收稿日期: 2016 － 01 － 25; 修回日期: 2016 － 05 － 20
基金项目: 国家自然科学基金( 81260095)
作者简介: 郑晶晶( 1981 － ) ，女，内蒙古医科大学附属医院妇产科医师，医学硕士。
通讯作者: 宋静慧，教授，硕士研究生导师，E － mail: songjinghui2002@ aliyun． com 内蒙古医科大学附属医院，
010050