目的: 研究预先注射罗库溴铵对全麻诱导期依托咪酯引发肌阵挛的影响。方法: 选择100 例男性病
人，ASAⅠ或Ⅱ级，年龄20 ～ 60 岁，全身麻醉下行择期手术。随机分为2 组罗库溴铵预给药组( R 组) 和对照组( S
组) ，每组50 例。两组病人先给予芬太尼3μg /kg，面罩吸氧2 min 后，R 组给予罗库溴铵0． 3 mg /kg，顺序注射依托
咪酯0． 3 mg /kg、罗库溴胺0． 3 mg /kg; B 组给与等容积生理盐水，依托咪酯0． 3 mg /kg、罗库溴胺0． 6 mg /kg，依托咪酯
的速度推注速度为1 mg /s。记录两组病人麻醉前( T1) 、给予依托咪酯后( T2) 、给予依托咪酯1 min 后( T3) 、插管
后( T4) HR、SBP、SPO2变化及肌震颤发生情况。结果: 两组病人一般情况差异无统计学意义( P ＞ 0． 05) 。麻醉诱导
过程中S 组在T2 时HR 明显高T1( P ＜ 0． 05) ，且在T2 时间点时S 组HR 较R 组心率增加( P ＜ 0． 05) ，SBP 及SPO2
无明显变化，无统计学意义( P ＞ 0． 05) 。与S 组比较，R组病人没有发生肌阵挛、肌阵发生率显著降低( P ＜0． 01) 。
结论: 罗库溴铵预给药对缓解依托咪酯引发的肌阵挛切实可行。

Objective: To observe the effects of pre － injection of Rocuronium on etomidate － induced
myoclonus in induction of anesthesia． Methods: 100 consenting ASA Ⅰ －Ⅱmale patients，aged
from 20 ～ 60 years were selected for undergoing elective surgery under general anesthesia． They were
randomly divided into rocuronium group( group R，n = 50) and saline group( group S，n = 50) ． All Patients
were given 3 ug /kg fentanyl and 2 min oxygen mask． Group R patients were received 0． 1 mg /kg
rocuronium， sequentially injected 0． 3 mg /kg etomidate，0． 5 mg /kg rocuronium; Group S were given
the same volume of saline，0 ． 3 mg /kg etomidate，0 ． 6 mg /kg rocuronium． Each group were infused etomidate
speed in 1 mg /s． The occurrence and severity of myoclonus were recorded，SBP、HP、SPO2 were
measured during the study period( before anesthesia T1、gave etomidate T2、1 min after gave etomidate
T3、after intubation) ． Results: There were no significant differences in general( P ＞ 0． 05) between two
groups． The HR were higher in group R than group S at T2( P ＜ 0． 05) ，and compared with group R，
the HR were higher in group S at T2( P ＜ 0． 05) ，SBP and SPO2 had no significant changes in the two
group( P ＞ 0． 05 ) ． The incidence of myoclonus was significantly lower in groupR ( 0%) than that
( 80%) in group S( P ＜ 0． 01) ． Conclusion: It’s feasible that Rocuronium pre － administration can relieve
Etomidate － induced myoclonus．

R452

 收稿日期: 2016 － 01 － 17; 修回日期: 2016 － 05 － 23
基金项目: 内蒙古自治区自然科学基金( 2015MS0803)
作者简介: 刘慧芳( 1982 － ) ，女，内蒙古医科大学附属医院麻醉科主治医师，医学硕士。
通讯作者: 温再和，主任医师，硕士研究生导师，E － mail: wenzaihe@ 126． com 内蒙古医科大学附属医院麻醉科，
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