目的: 探讨P53、P63 蛋白的表达与腮腺恶性肿瘤的发生发展，生物学行为的相关性。方法: 收集内
蒙古医科大学附属医院和青岛口腔医学院口腔颌面外科2006 ～ 2016 年腮腺恶性肿瘤癌以及癌旁组织存档蜡块
标本40 例。标本经资深病理专家确诊，并具有完整的临床资料，证实术前均未经放化疗。采用免疫组化S－P 法
检测P53、P63 蛋白的表达，采用SPSS 13．0统计软件进行统计分析，应用χ² 检验，P＜0．05具有显著性差异，有统
计学意义。结果: 1．P53 蛋白在腮腺恶性肿瘤癌组织中的表达均高于癌旁组织，两者有显著性差异( P＜0．05) ，其
表达与恶性度有关，而与病人性别，年龄，淋巴结转移无关。2．P63 蛋白在腮腺恶性肿瘤癌组织中的表达均高于
癌旁组织，两者有显著性差异( P＜0．05) ，其表达与病人性别，年龄，淋巴结转移，恶性度无关。3．腮腺恶性肿瘤的
癌组织中P53、P63 蛋白的表达互相间无显著性差异( P＞0．05) 。结论: P53、P63 蛋白在腮腺恶性肿瘤病人癌组
织中呈高表达，P53 蛋白表达并与生物学行为有关。P53、P63 蛋白有可能在腮腺恶性肿瘤的发生过程中发挥一
定的作用，对腮腺恶性肿瘤的诊断可提供重要参考价值。

Objective: To discuss the correlation between expression of P53，P63 protein and the
genesis，development and biological behavior of parotid gland malignant tumors．Methods: 40patients
pathologically confirmed parotid gland malignant tumors were collected in two institutes in the decade
to2010．The cases were confirmed with no chemoradiotherapy before operation．Expression of P53，P63
were detected by immunohistochemical S－P method．Statistical analysis was performed using the chisquare
test．Results: P53 and P63 protein were higher expressed in parotid gland malignant tumor than
in para－carcinoma tissues with significant．difference．The expression of P53 protein was associated with
the degree of malignancy，but not with gender，age or lymphatic metastasis． There was no significant
difference among expression of P53，P63 protein in malignant parotid gland tumors( P＞0．05) ． In the
follow－up，only one patient died of colon cancer．Conclusion: P53 and P63 protein were highly expressed
in these cases， the expression of P53 protein was correlated with biological behavior of parotid
gland malignant tumor．P53 and P63 protein may play a certain role in genesis and development of parotid
gland malignant tumor，and provide an important reference for clinical diagnosis value．

R394．4

 收稿日期: 2016－04－23; 修回日期: 2016－08－10
基金项目: 内蒙古自治区自然科学基金( 2011MS1138)
作者简介: 咏梅( 1969－) ，女，内蒙古医科大学附属医院口腔科主任医师，医学硕士。
通讯作者: 苏秀兰，教授，主任，博士生导师，E－mail: xlsu@ hotmail．com 内蒙古医科大学附属医院， 010050