目的: 本课题通过检测不同分娩方式新生儿脐血中NK 细胞含量，探讨其与婴儿早期发生过敏性皮
疹的相关性，为临床婴幼儿湿疹的防治提供理论依据。方法: 选取我院2013－03 ～ 2014－03 生产的产妇99 例，分
为剖宫产组和自然分娩组，采用流式细胞仪检测新生儿脐血中NK 细胞。并在新生儿出生后6mo 进行电话随
访，了解过敏性皮疹的发生情况。结果: ( 1) 剖宫产、自然分娩两组孕母年龄、胎儿性别、胎龄差异均无统计学意
义( P＞0．05) ; ( 2) 剖宫产组新生儿脐血NK 细胞水平低于自然分娩组( P＜0．01) ; ( 3) 生后6mo 时剖宫产组新生儿
发生过敏性皮疹例数多于自然分娩组( P＜0．05) 。结论: ( 1) 剖宫产组新生儿脐血NK 细胞水平较自然分娩组低，
提示脐血中NK 细胞减少可能影响到其免疫功能的完善; ( 2) 剖宫产组新生儿生后6mo 时过敏性皮疹的发生率
较自然分娩组明显增高，说明剖宫产新生儿更容易发生过敏性皮疹; ( 3) 脐血NK 细胞水平可能与新生儿与婴儿
早期过敏性皮疹的发生有关; ( 4) 新生儿非特异性免疫受可能也受分娩方式的影响。

Objective: This topic through the detection of different delivery methods of neonatal
cord blood Natural killer cells content， to explore the correlation with the baby’s early occurrence of allergic
skin rash， to provide a theoretical basis for the prevention and treatment of infantile eczema．
Methods: 99cases of pregnant women in our hospital from March 2013 to March 2014 were selected
and divided into cesarean section and natural delivery group．NK cells were detected by flow cytometry．
And in June after the birth of a telephone follow－up， to understand the occurrence of allergic skin rash．
Results: ( 1) There was no significant difference in the age of the two groups of maternal age， fetal sex
and age between the groups( P＞0．05) ; ( 2) The level of umbilical cord blood NK cells in cesarean section
was lower than that in natural labor group( P＜0．01) ; ( 3) The number of cases of allergic rash occurred
more than the natural childbirth group( P＜0．05) in the 6months after birth．Conclusions: ( 1)
The level of umbilical cord blood NK cells in cesarean section was lower than that in the natural delivery
group， suggesting that the decrease of NK cells in cord blood may affect the improvement of its immune
function; ( 2) The incidence of allergic skin rash was significantly higher in the 6months after
birth than in the spontaneous delivery group，which showed that the newborn infants were more likely to
have an allergic rash; ( 3) Umbilical cord blood NK cells may be associated with the occurrence of neonatal
early allergic skin rash; ( 4) Nonspecific immunity in newborn infants may also be affected by delivery
methods．

R714．3

 收稿日期: 2016－09－08; 修回日期: 2016－10－11
基金项目: 内蒙古自治区医疗卫生科研计划项目( 201403079)
作者简介: 冯荣光( 1982－) ，男，内蒙古妇幼保健院住院医师。
通讯作者: 张玉玲，副主任医师，E－mail: Luckydourui@ xinlang．com 内蒙古妇幼保健院内科， 010020