[关键词]
[摘要]
川崎病已逐渐代替风湿热成为儿童后天性心脏病的主要原因之一，但目前该病的发病诱因以及发
病机制尚未明确。建立川崎病的动物模型可为找到川崎病的发病诱因及研究其发病机制提供重要实验基础。
自川崎病发现以来，很多学者利用各种诱导剂，如白色念珠菌，干酪乳杆菌，牛血清，马血清等在动物中来诱导产
生川崎病动物模型，其中小鼠为研究最多应用最广的动物模型，用这些模型进一步研究川崎病的发病诱因及其
发病机制，并取得一定进展。本文将对现有川崎病动物模型及其相关的评价与应用作一综述。
[Key word]
[Abstract]
Kawasaki disease has gradually replaced rheumatic fever became one of the major cause
of acquired heart disease in children，but its etiology and pathogenesis has been unclear．However，animal
model of Kawasaki disease has provided an important foundation of etiology and pathogenesis research．
Since the Kawasaki disease discovered，Many scholars use kinds of inducers， such as Candida，
Lactobacillus casei，bovine serum and horse serum injected to animals such as mice， rabbit dog and
swine to build animal model of Kawasaki disease，and use these model for further study on etiology and
pathogenesis of Kawasaki disease．This article summarize the existing animal model of Kawasaki disease
and its associated evaluation and application．
[中图分类号]
R725．4
[基金项目]
收稿日期: 2016－08－11; 修回日期: 2016－09－29
基金项目: 内蒙古科技厅科技计划项目( 2014)
作者简介: 刘潇婷( 1990－) ，女，内蒙古医科大学2014 级在读硕士研究生。
通讯作者: 朝鲁门，主任医师，教授，硕士研究生导师，E－mail: chaolumenqi@ 126．com 内蒙古医科大学附属医院儿科，
010050
