[关键词]
[摘要]
目的: 探讨老年病人胱抑素C、血尿酸( SUA) 、总胆红素与最大颈动脉内膜中层厚度( cIMT) 的关系。
方法: 选取2016-07 在内蒙古自治区人民医院住院的306 例60 岁以上老年病人。采用颈动脉超声检查测定病
人最大颈动脉内膜中层厚度( cIMT) ,将病人分为cIMT 正常组( A 组) 和cIMT 增厚组( B 组) 。比较两组病人胱
抑素C、血尿酸、总胆红素、年龄、空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂
蛋白胆固醇等危险因素,并分析上述因素对最大颈动脉内膜中层厚度的影响。结果: ( 1) A 组胱抑素C、血尿酸、
总胆红素低于B 组( P<0.05) 。( 2) Spearman 相关分析显示cIMT 与年龄、总胆固醇、胱抑素C、血尿酸正相关相
关( r = 0.189,0.198,0476,0.236) ,与高密度脂蛋白胆固醇、总胆红素负相关( r = -0.190,-0.256) 。Logistic 回归分
析显示cIMT 与年龄、总胆固醇、高密度脂蛋白胆固醇、胱抑素C、血尿酸、总胆红素相关( P<0.05) ,cIMT 与年龄、
总胆固醇、胱抑素C、血尿酸正相关相关,与HDL、总胆红素负相关。结论: 除年龄、空腹血糖、糖化血红蛋白、甘
油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血肌酐外,胱抑素C、血尿酸、总胆红素也是颈动
脉粥样硬化的重要因素。
[Key word]
[Abstract]
Objective: To investigative the relation between cystatin C serum acid and total
bilirubin with maximum intima - media thickness in Elderly patients. Methods: 306Elderly patients
above 60 years old treated in The Inner Mongolia autonomous region people’s hospital were collected in
the study.According to maximum carotid intima-media thickness( cIMT) by color Dopper, the subjects
were divided into the Normal cIMT group( Group A) and cIMT increased group( Group B) .The cystatin
C,serum acid level,total bilirubin,total cholesterol,age,Fasting blood glucose,glycosylated
hemoglobin, triglyceride,High density lipoprotein cholesterol,Low density lipoprotein cholesterolwere
compared between the two different groups.Results: Group A,Cystatin C,uric acid, total bilirubin lower
than group B( P<0.05) . Spearman correlation analysis showed that cIMT with age, total cholesterol,
Cystatin C, serum uric acid is associated related( r = 0.189,0.1980476,0.236) and high density lipoprotein
cholesterol, total bilirubin negative( r = -0.190. -0.256) .Logistic regression analysis showed that
cIMT with age, total cholesterol,high density lipoprotein cholesterol,Cystatin C, serum uric acid, total
bilirubin( P<0.05) ,cIMT with age, total cholesterol,Cystatin C,uric acid is related to,and HDL, total
bilirubin negative correlation.Conclusions: cystatin C, serum acid level, total bilirubin were important
factors for atherosclerosis.
[中图分类号]
R543.5
[基金项目]
收稿日期: 2016-12-19; 修回日期: 2017-02-22
基金项目: 国家自然科学基金( 81460223)
作者简介: 刘颖( 1988-) ,女,包头医学院2015 级在读硕士研究生。
通讯作者: 高金娥,主任医师,硕士研究生导师,E-mail: 2698119597@ qq.com 内蒙古自治区人民医院, 010017