[关键词]
[摘要]
目的:正交设计法优化喜树碱胶束的制备工艺。方法: 采用透析法制备喜树碱胶束，在单因素考察
的基础上，以投料比、pH 值、透析温度为影响因素，药物包封率为指标，应用正交设计法优化载药胶束的制备工
艺，并对最佳工艺进行重复性实验。结果:喜树碱胶束的最佳制备工艺为: 聚合物材料与药物的投料比为1: 10、
pH 值为5、透析温度为30℃。重复性实验结果表明，载药胶束的平均包封率为51．86%，RSD 为0．11%。结论: 最
佳制备工艺制得胶束的包封率均高于正交试验结果，该制备工艺稳定可行，成功实现了难溶性药物喜树碱的增
溶，为喜树碱胶束的制备提供了实验依据，为提高此类难溶性药物的临床疗效奠定了基础。
[Key word]
[Abstract]
Objective:The research aimed to optimize the preparation technology of camptothecin
micelles by orthogonal design．Methods:The drug loaded micelles were prepared by dialysis method．
The orthogonal tests were used to optimize the preparation technology involving feed ratio，pH value and
temperature．Results:The optimal preparation technology of dialysis method was that the feeding ration
was 1:10，pH value was 5，the temperature was 30℃．The repeat test shows that the encapsulation rate
was up to 51．86% with high stability as RSD = 0．11%． Conclusion: The optimized preparation
technology of camptothecin micelles was stable and feasible．Successfully solve the problem of insoluble
drug CPT．
[中图分类号]
R94
[基金项目]
收稿日期: 2017－02－01;修回日期: 2017－03－01
基金项目: 内蒙古自治区自然科学基金(2013MS1209)
作者简介: 刘佳(1982－)，女，内蒙古医科大学药学院药剂教研室讲师，药剂学硕士。
通讯作者: 顾艳丽，教授，硕士研究生导师，E－mail:gyl0903@ sina．com 内蒙古医科大学药剂教研室，010010
