目的: 探讨Ki－67 在胃癌中的表达及其与氟脲嘧啶类化疗药的相关性。方法: 收集本院病理诊断明
确的胃癌病人资料69 例，且满足术后以氟脲嘧啶类药物为主的联合化学治疗，免疫组织化学方法检测胃癌病人
Ki－67 的表达情况及其与氟脲嘧啶类化疗药的相关性。结果: 胃癌病人Ki－67 阳性表达率随腺癌分化程度变
化，分化程度越低表达越高( P＜0．05) ，淋巴结转移病人组阳性表达率高于非淋巴结转移组( P＜0．05) ，且与胃癌
浸润深度正相关( P＜0．05) ; 同时Ki－67 表达阳性病人临床有效率和疾病控制率明显高于表达阴性病人( P＜
0．05) ，Ki－67 表达阳性率与氟脲嘧啶类药物敏感性相关( P＜0．05) 。结论: Ki－67 的表达与胃癌组织病理类型、
淋巴结转移、分化程度及氟脲嘧啶类药物化疗敏感性相关，Ki－67 的表达可作为氟脲嘧啶类药物临床化疗选择
方案的预测因子。

Objective: To investigate the expression of Ki－67 in gastric cancer and its effect on the
fluoropyrimidines drugs．Methods: Retrospective analysis was carried out in 69 gastric cancer patients，
who were treated on fluoropyrimidine based combined chemotherapy after operation．the expression of Ki
－ 67 was detected by immunohistochemical method，statistical analysis its expression in gastric
carcinoma and its effect on fluorouracil chemotherapy drugs．Results: In gastric cancer patients， the Ki－
67 positive expression rate were gradually increased，with the decrease of the degree of differentiation of
gastric cancer( P＜0．05) ; Ki－67 positive expression rate in patients with lymph node metastasis was
significantly higher than those in patients without lymph node metastasis( P＜0．05) ; Positive rate of Ki－
67 expression in invasive cancer was higher than those in less invasive cancer．( P＜0．05) ．The clinical
efficiency and disease control rate for gastric cancer patients with Ki－67 expression positive was significantly
higher than that of patients with negative expression( P＜0．05) ．The positive rate of Ki－67 ex-
pression in the two groups( sensitive for fluoropyrimidines drugs vs insensitive groups) was statistically
significant( P＜0．05) ．Conclusion: The expression of Ki－67 was correlated with the degree of differentiation，
lymph node metastasis， infiltration depth and the sensitivity of fluoropyrimidines drugs． The expression
of Ki－67 can be used as a predictive factor for the selection of fluoropyrimidines drugs．

R735．2

 收稿日期: 2017－02－18; 修回日期: 2017－05－03
基金项目: 内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目( 201303124) ;
内蒙古自治区自然科学基金( 2016MS0899)
作者简介: 华云旗( 1981－) ，男，包头市肿瘤医院肿瘤内科副主任医师。
通讯作者: 刘险峰，主任医师，E－mail: hyqyfr@ 126．com 包头市肿瘤医院， 014030