目的: 回顾性分析¹⁸F－FDG PET/CT 对非霍奇金淋巴瘤( non－Hodgkin’s lymphoma，NHL) 化疗效果及
预后评估的临床应用价值。方法: 收集2011－01～ 2016－01 在内蒙古医科大学附属医院经病理检查确诊的NHL
病人108 例，化疗中期( 3～ 4 个疗程后) 行¹⁸F－FDG PET/CT 显像，并随访6 ～ 60mo，分析PET 和同机CT 的结果，
对病灶行临床综合评估，应用无进展生存( progression free survival，PFS) 期及总体生存( Overall survival，OS) 期作
为随访指标，进行疗效评价。率的比较采用χ² 检验，病人的生存分析采用Kaplan－Meier 方法。结果: 中期疗效
评价中，与临床综合评估结果比较，阳性58 例，阴性50 例。¹⁸F－FDG PET 灵敏度、特异性及准确性分别为82．8%
( 48 /58) 、78．0%( 39 /50) 及80．6%( 87 /108) ，而CT 检查分别为53．4%( 31 /58) 、64%( 32 /50) 及58．3%( 63 /108) ，¹⁸
F－FDG PET 对NHL 诊断的灵敏度、特异性及准确性均高于CT 检查，差异均有统计学意义( P＜0．05) 。PET 阳性
者及阴性者的中位PFS( progression－free survival) 期分别35mo 和45mo，差异有统计学意义( χ² = 31．71，P= 0．00) 。
结论: ¹⁸F－FDG PET/CT 显像在非霍奇金淋巴瘤疗效评价及预后判断有重要临床价值，优于传统影像学检查。

Objective: To investigate the application value of ¹⁸F－fluordeoxyglucose positron emission
computed tomography /computed tomography( ¹⁸F－FDG PET /CT) in monitoring response to chemotherapy
and prognosis of non－Hodgkin’s lymphoma( NHL) ．Methods: We collected 108 patients with
non－Hodgkin’s lymphoma who have been Confirmed by pathological examination in the Affiliated Hospital
of Inner Mongolia Medical University from January 2011 to January 2016，and were monitored by
¹⁸F－FDG PET /CT before chemotherapy and after 3～4 courses of chemotherapy．We follow up patients
in 6～60months．We analysed ¹⁸F－FDG PET /CT and CT scan in same machine，we comprehensive
evaluate lesion．Predict progression free survival( PFS) and overall survival( OS) ，we statistical analysis
the results by chi－square test and Kaplan－Meier．Results: We evaluated the lesion response to chemotherapy
at metaphase with clinical comprehensive analysis， it showed positive in 58 cases and negative
in 50 cases．the sensitivity， specificity，accuracy of ¹⁸F－FDG PET in evaluation of response to treatment
in NHL were 82．8%( 48 /58) 、78．0%( 39 /50) and 80．6%( 87 /108) ，which were significantly higher
than those of CT scan in same machine， It was 53．4%( 31 /58) 、64%( 32 /50) and 58．3%( 63 /108) ，P＜
0．05．The progression－free survival( PFS) were 35months and 45months in PET positive and negative
patients respectively， the difference was statistically significant，( χ² = 31．71，P = 0．00) ．Conclusion: ¹⁸F
－FDG PET /CT has significant value in monitoring response to therapy and predicting prognosis for patients
with NHL．It is superior to traditional imaging．

R551．2

 收稿日期: 2017－03－03; 修回日期: 2017－09－01
基金项目: 内蒙古医科大学青年创新基金( YKD 2012 QNCX004)
作者简介: 王春梅( 1982－) ，女，内蒙古医科大学核医学科主治医师，医学硕士。