[关键词]
[摘要]
受环境、生活方式等多种因素的影响，乳腺癌成为危害女性健康的恶性肿瘤，因此寻找敏感且特异
性高的肿瘤标志物以及对乳腺癌进行预防和诊治很有必要。研究表明，CEA、CA199、CA125、CA153 等肿瘤标记
物的联合应用对乳腺癌的早期诊断和预后判断起了很大作用，但这些血清标志物在特异性和灵敏度方面，尤其
是单独使用时存在一定缺陷，因此寻找新的肿瘤标记物来补充乳腺癌的早期诊断及预后评估有很大的研究和应
用价值。微小ＲNA( microＲNA，miＲNA) 和外泌体( Exosomes) 作为新的肿瘤标记物与乳腺癌的治疗及预后相关，
因其高灵敏度和高特异性成为新的乳腺癌诊断早期标志物。
[Key word]
[Abstract]
Breast cancer，which was associated with lots of risk factors including environmental factors
and personal lifestyle，plays an important role in female health．Previous studies have demonstrated
that the combined application of tumor markers such as CEA，CA199，CA125 and CA153 are useful for
the early diagnosis and prognosis，however， the disadvantage for both the sensitively and specificity of
the application exists．The further development of new tumor markers can provide clues for early diagnosis
and prognosis，which is valuably．This study has a systematic review and focus on new tumor markers，
which can provide the further understanding of microRNAS and Exosomes．
[中图分类号]
R737．9
[基金项目]
收稿日期: 2017－03－18; 修回日期: 2017－08－28
基金项目: 内蒙古自治区人民医院院内项目( 201528)
作者简介: 曹银芳( 1977－) 女，内蒙古自治区人民医院副主任检验师。
通讯作者: 丁海涛，主任检验师，E－mail: nmgyy2302@ 163．com 内蒙古自治区人民医院， 010017
