目的: 探讨BＲCA－1、PAＲP－1 的表达变化与乳腺组织、三阴乳腺癌及非三阴乳腺癌的关系，探讨其
在三阴乳腺癌治疗、预后评估中的预测价值，以期望PAＲP－1 及BＲCA－1 成为新的预测影响因子，为治疗靶点提
供理论依据。方法: 收集我院2015－08～ 2016－08 期间病人的新鲜乳腺组织共90 例。采用ＲT－PCＲ 技术进行分
析，分别研究BＲCA－1、PAＲP－1 在不同乳腺组织表达差异，说明BＲCA－1、PAＲP－1 在三阴乳腺癌发生、发展中
的作用。结果: ( 1) 三阴乳腺癌的BＲCA－ 1 的表达低于非三阴乳腺癌( t = 3．202，P＜ 0．001) ; 乳腺恶性肿瘤的
BＲCA－1 的表达低于乳腺良性肿瘤( t = 9．335，P＜0．001) ; 且BＲCA－1 在乳腺肿瘤中的表达，不论良恶性，都低于
正常乳腺组织( t = 18．813，P＜ 0．001) 。( 2) 三阴乳腺癌的PAＲP － 1 的表达高于非三阴乳腺癌( t = 5．622，P＜
0．001) ; 乳腺恶性肿瘤的PAＲP－1 的表达高于乳腺良性肿瘤( t = 10．673，P＜0．001) ; 且PAＲP－1 在乳腺肿瘤中的
表达，不论良恶性，都高于正常乳腺组织( t = 10．016，P＜0．001) 。( 3) 随着BＲCA－1 表达值的增高，PAＲP－1 的表
达呈下降趋势，两者呈负相关( r = －0．817，P＜0．001) 。结论: BＲCA－1 参与乳腺癌的发生发展，随着肿瘤恶性程度
的增加，BＲCA－1 的表达呈下降趋势，在三阴乳腺癌中的表达高于非三阴乳腺癌，随着肿瘤恶性程度的增加，
PAＲP－1 的表达呈上升趋势，在三阴乳腺癌中的表达高于非三阴乳腺癌。

Objective: To analyze the predictive value of BＲCA－1 and PAＲP－1 expression in normal
breast tissues， triple negative breast cancer and non－triple negative breast cancer，and discusses its
treatment and prognostic evaluation of predictive value in triple negative breast cancer， in order to expect
PAＲP－1 and BＲCA－1 to become the new predictive factors，which will provide theoretical basis
for the therapeutic target．Methods: Collecting 90 cases of fresh breast tissue we used ＲT － PCＲ to
measure BＲCA－1 and PAＲP－1 expression levels， to investigate the difference of expression of BＲCA－
1 and PAＲP－1 in different breast tissues，and to analyze the correlation between BＲCA－1 and PAＲP－
1 and breast cancer patients’age，sex， tumor diameter，depth of invasion，degree of differentiation，
lymph node metastasis，TNM stage and follow－ups after operation and its prognosis．Ｒesults: ( 1) The
expression of BＲCA－1 in the TNBC is lower than that in the non－TNBC( t = 3．202，P＜0．001) has statistical
significance．The expression of BＲCA－1 in the breast tumors is lower than that in the normal
breast tissues( t = 18．813，P＜0．001) ( 2) The expression of PAＲP－1 in the TNBC is lower than that in
the non －TNBC( t = 3．202，P ＜ 0．001) has statistical significance． The expression of PAＲP － 1 in the
breast tumors is higher than that in the normal breast tissues( t = 10．016，P＜0．001) ( 3) With the increasing
of the expression of the BＲCA－1， the expression of the PAＲP －1 is decreasing， so the both
ways are negatively correlated with statistical significance( r = －0．817，P＜0．001) ．Conclusion: With the
development of breast cancer， the expression of the BＲCA－ 1 is decreasing with the increase of the
tumors’ malignant degree．The expression of the BＲCA－1 in triple negative breast cancer is higher than
that in non －triple negative breast cancer，which will become a new target for screening therapeutic
method．Nevertheless， the expression of the PAＲP－1 is increasing with the rising of the tumors’ malignant
degree involved in the development of breast cancer．The expression of the PAＲP－1 in triple negative
breast cancer is higher than that in non－triple negative breast cancer， the PAＲP－1 inhibitor may
benefit from the treatment of TNBC as a target of inhibitor．

Ｒ 730．3

 收稿日期: 2017－07－06; 修回日期: 2017－10－09
基金项目: 内蒙古自治区人民医院院内基金( 201305)
作者简介: 李文新( 1968－) ，男，内蒙古自治区人民医院肿瘤内科主任医师，医学硕士。