目的: 本横断面筛查研究旨在调查中国南方人群高尿酸血症及其相关疾病患病率，同时探索高尿酸
血症的危险因素。方法: 所有参与者分为三个组: 男性组、绝经前女性组和绝经后女性组。计算高尿酸血症及其
相关疾病的患病率，应用Logistic 回归模型来探索高尿酸血症的潜在危险因素。结果: 1834 例受试者纳入数据
分析，男性、绝经前女性和绝经后女性高尿酸血症的患病率分别是42．71%、15．06%、34．25%。在男性和女性组
中，慢性肾脏病、腰围、高甘油三酯与高尿酸血症相关，但年龄和高血压仅在女性中与高尿酸血症显著相关。结
论: 高尿酸血症的患病率男性高于女性、绝经后女性高于绝经前女性。在男性和女性中，慢性肾脏病、腰围、甘油
三酯升高与高尿酸血症相关。

Objective: The objective of this study is to investigate prevalence of hyperuricemia and
its comorbidities in a Southern Chinese population．We also explored the risk factors for hyperuricemia．
Methods: All participants were divided into three subgroups: men，premenopausal and postmenopausal
women．Logistic regression models were used to explore the potential risk factors for hyperuricemia．Ｒesults:
1834 participants were included in the analyses．The prevalences of hyperuricemia in men，premenopausal
women and postmenopausal women were 42．71%、15．06%，and 34．25%， respectively．CKD，
waist circumference and elevated serum triglyceride are associated with hyperuricemia in both women
and men． Age and elevated blood pressure are only significantly associated with hyperuricemia in
women．Conclusion: Hyperuricemia is common and men have a higher prevalence of hyperuricemia than
women．Postmenopausal women have a higher prevalence than premenopausal women．CKD，waist circumference
and elevated serum triglyceride are associated with hyperuricemia．

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 收稿日期: 2017－09－08; 修回日期: 2017－10－23
基金项目: 国际肾脏病学会资助项目( 2004－2014) ; 广东省科技计划项目( 2011B031800386)
作者简介: 张丽英( 1979－) ，女，内蒙古医科大学附属医院肾内科副主任医师。