目的: 探讨大Y 染色体核型在流产、死胎等不良妊娠结局中的生物、临床意义。方法: 采用病例对照
分析法，收集2010－02～ 2017－04 在内蒙古医科大学第一附属医院就诊或咨询的2252 对存在不良妊娠结局史的
育龄夫妇纳入研究，实验人群均为男性，采用常规外周血细胞培养及染色体标本制备、G 显带核型分析，同时将
同期920 对无流产史、曾足月分娩的正常夫妇纳入对照组，比较不同组别间大Y 检出率的统计学差异，并探讨大
Y 染色体的临床意义。结果: 不良妊娠组2252 例受检标本中，共检出833 例大Y 染色体核型，检出率为36．99%;
对照组920 例受检标本中，检出大Y 核型97 例，检出率为10．54%，组间差异有统计学意义( P＜0．05) ; 不良妊娠
组中大Y 核型检出者具有临床效应者( 少弱畸精症、无精症、睾丸或附睾发育不良等) 为289 例，占34．69%，对照
组中大Y 核型检出者中具有临床效应者为5 例，占5．15%，两组间差异有统计学意义( P＜0．05) 。结论: 大Y 染色
体核型在遗传生殖方面存在一定的临床效应，在流产、死胎等不良妊娠结局发生因素中具有临床意义。

Objective: To investigate the biological and clinical significance of large Y chromosome
nuclear type in the end of miscarriage and fetal death．Methods: Through case study and comparison，
collecting 2010－02～2017－04 in Inner Mongolia medical university first affiliated hospital or consulting
of 2252 couples of childbearing age，which is in the history of adverse pregnancy outcomes included in
the study，experimental group as the object of male， the conventional peripheral blood cell culture and
chromosome specimen preparation，G banding karyotype analysis，and there is no history of miscarriage，
will be in the same period of 920 to normal once term couple into the control group，comparing each big
Y detection rate statistically，and to explore the clinical significance of the big Y chromosome．Ｒesults:
In 2252 specimens，833 cases of large Y chromosome were detected and 36．99%were detected．In the
control group 920 specimens，97 were detected in the large Y nuclear type， the detection rate was
10．54%，and the difference in the group was statistically significant( P＜0．05) ．Adverse pregnancy group
cuhk Y karyotype detection with clinical effect for the( little weak abnormal disease，no refined disease，
testis and epididymis dysplasia，etc．) for 289 cases，accounting for 34．69%，control group cuhk Y karyotype
detection with clinical effect in for 5 cases，accounted for 5．15%， the difference between the two
groups was statistically significant( P＜0．05) ．Conclusion: big Y chromosome karyotype in genetic reproduction
of certain clinical effect， such as abortion， stillbirth，bad pregnancies occur factors have clinical
significance．

Ｒ714

 收稿日期: 2017－05－13; 修回日期: 2017－10－13
基金项目: 内蒙古自治区自然科学基金项目( 2010MS1103)
作者简介: 武艾宁( 1971－) ，女，内蒙古医科大学附属医院妇产科主治医师。
通讯作者: 戴晓怡，主任医师，E－mail: Wuaining1971@ 163．com 内蒙古医科大学附属医院， 010050