目的: 探讨人乳头瘤病毒( HPV) 感染与阴道微生态的相关性，进而为调节阴道微生态失衡、避免或
减少病人感染HPV 提供科学依据。方法: 选取2017－01～ 2017－12 期间我院门诊HPV 检测阳性的病人70 例作
为观察组，同期HPV 检测阴性的病人70 例作为对照组。两组病人均行阴道微生态检测，分析两者之间的相关
性。结果: 观察组的微生态失调发生率为70．00%( 49 /70) ，对照组为18．57%( 13 /70) ，差异具有统计学意义( P＜
0．05) 。阴道清洁度3～ 4 度者感染HPV 的可能性明显高于清洁度1～ 2 度者。两组线索细胞检出率差异无统计
学意义( P＞0．05) ，观察组的乳酸杆菌、念珠菌、滴虫感染检出率与对照组相比，差异具有统计学意义( P＜0．05) 。
尤其乳酸杆菌与微生态失调以及HPV 感染关系密切( P＜0．05) 。结论: HPV 感染病人存在明显的阴道微生态失
调状况，主要表现为乳酸杆菌检出率降低。

To explore the relationship human papillomavirus virus( hpv) infection and vaginal microenvironment
to provide scientific basis for the regulation of vaginal microecologicol balance and human
papillomavirus virus infection．Methods: 70 cases of HPV－positiv from February 2016 to December
were selected as the observation group，with 70 cases of HPV－negative during the same period as the
controrol group．The vaginol bacteria were dectected in the two groups，and the correlation among the above－
mentioned factor was analyzed．Ｒesults: The incidence rate of microdystionsis was 70．00%in the
observation group vs 18．57%in the controrol group， the difference was significant( P＜0．05) ．the cases
with 3 or 4 degrees of vagina cleaness had more possibility of infection of HPV and occurrence of cervical
lesions than the cases of 1 or 2 degrees of vagina cleaness．The derection arates of the clue cells
were no significantly different between the two groups( P＞0．05) ，but were those of lactic acid bacteria，
Trichomonas and candida( P＜0．05) ．Conclusion: There are obvious microecdogicol imbalance in HPV
infection patients，which can be manifeststed as the low detection rate of lactic acid bacteria．

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