[关键词]
[摘要]
目的: 研究蒙药复方森登-4 对小鼠抗炎镇痛的作用。方法: 采用肉芽肿实验法,涂二甲苯至小鼠耳
廓使耳朵肿胀法观察抗炎作用; 采用腹腔注射醋酸致小鼠扭体法观察镇痛作用。结果: 各剂量组与模型组比较,
得出: 蒙药复方森登-4( 135 mg /kg) 组能抑制棉球致小鼠肉芽肿的生长,肉芽肿的重量为18.7±0.86mg; 抑制二甲
苯致小鼠耳肿胀,抑制率29.69%; 抑制冰醋酸引起的小鼠扭体反应,抑制率40.04%。结论: 蒙药复方森登-4 对小
鼠有显著的抗炎镇痛作用。
[Key word]
[Abstract]
Objective: To study the anti-inflammatory and analgesic effects of Mongolian medicine
compound Sendeng- 4 in mice.Methods: The anti -inflammatory effects were observed by the cotton
ball granuloma, the methods of mice ear swelling.The analgesia effects were observed by the methods of
writhing body.Results: Compared with model group,Mongolian medicine compound Sendeng - 4( 135
mg /kg) could inhibit the growth of the cotton granuloma in mice, the weight of granuloma is 18.7±0.86
mg and ear swelling induced by dimethylbenzene, inhibition ratio is 29.69%, inhibit the writhing body
reaction induced by acetic acid, inhibition ratio is 40.04%.Conclusion: Mongolian medicine compound
Sendeng-4 has anti-inflammatory and analgesic effects.
[中图分类号]
R965.1
[基金项目]
收稿日期: 2018-01-03; 修回日期: 2018-03-15
基金项目: 2017 年国家自然科学基金项目( 81660703) ; 2016 年自治区级大学生创新创业训练计划项目; 2017 年内蒙
古医科大学大学生科技创新基金。
作者简介: 王冰雨( 1993-) ,女,内蒙古医科大学2016 级硕士研究生。
通讯作者: 董玉,教授,博士,博士生导师,E-mail: dongyu010@ 126.com 内蒙古医科大学药学院, 010110