目的:通过检测血浆D－二聚体在深二度重度兔烫伤后的变化，以及深二度重度兔烫伤后不同时期
合并肺栓塞时血浆D－二聚体的变化，探讨测定D－二聚体对深二度重度烫伤后合并急性肺栓塞的诊断的指导意
义。方法: 健康中国大耳白兔48 只，雌雄不拘，随机分为: 分为对照组、烫伤组、烫伤休克期组、烫伤休克期+肺
栓塞组、烫伤感染期组、烫伤感染期+肺栓塞组，每组8 只。烫伤组与对照组分别于造模后1 d、3 d、5 d、7 d、14 d、
21 d 采血检测D－二聚体，其他组于造模后30 min、1 h、3 h、6 h、24 h 采血应用酶联免疫法检测D－二聚体。结果:
烫伤组与对照组相比，D－二聚体1 d、3 d、5 d、7 d 表达高于对照组( P＜0．05) ; 烫伤休克期+肺栓塞组与烫伤休克
期组相比，D－二聚体的表达差异有显著性( P＜0．05) ; 烫伤感染期+肺栓塞组与烫伤感染期组相比，D－二聚体的
表达差异亦有显著性( P＜0．05) 。结论: D－二聚体的表达在各组间都有差异性，D－二聚体可作深二度重度烫伤
合并肺栓塞的诊断指标之一。

Objective: To detect the changes of plasma D－dimer in severely burnt rabbits on deep
partial thickness wound and in different phases with pulmonary embolism，so as so explore the significance
of D－ dimer in the diagnosis of acute pulmonary embolism on deep partial thickness wound．
Methods: 48 healthy Chinese white rabbits，male or female，were randomly divided into: control group，
burn group，burn shock group，burn shock+pulmonary embolism group，scald infection phase group and
burn infection +pulmonary embolism group，with 8 rabbits in each group．By the ELISA method，D－dimer
were determion on 1d，3d，5d，7d，14d in the burn group and the control group after the model being
built and in 30 min，1h，3h，6h，24h in the other groups after the model being built．Ｒesults: D－dimer
expression in the burn group were higher than in the control group on 1d、3d、5d、7d．There were
obvious difference of expression of D－dimer in the burn shock group and the burn shock+ pulmonary
embolism group．There were the same obvious difference of expression of D－dimer in the scald infection
phase group and burn infection +pulmonary embolism group．Conclusion: There were no differences of
the expression of D－dimer in each group．The D－dimer can be used to predict in the diagnosis of pulmonary
embolism on the deep partial thickness severe burn wound．

Ｒ563．5