目的:比较ABO 血型病人口服阿司匹林后，血小板功能指标变化情况，探讨阿司匹林的抗血小板作
用，以及阿司匹林抵抗相关的环氧化酶－1( cyclo－oxygen－ase－1，COX－1) 基因位点rs1330344 的基因型在ABO 血
型间是否存在差异。方法: 80 例心肌缺血并颈部动脉粥样硬化需口服阿司匹林病人，根据ABO 血型分为4 组( n
= 20) ，分别为A 血型组( A 组) ，B 血型组( B 组) ，O 血型组( O 组) 和AB 血型组( AB 组) 。比较病人口服阿司匹
林前( T1) 以及服药1wk 后( T2) 血小板计数( PLT) 、血小板平均体积( MPV) 及血栓弹力图最大血块强度( TEGMA)
的变化。采用PCＲ 法测定COX－1 基因位点rs1330344 基因型。结果: T2 与T1 比较，O 组PLT、MPV、TEGMA
均减小( p＜0．05) ; AB 组TEG－MA 增大( p＜0．05) 。与A 组及O 组比较，AB 组TEG－MA 服药前后差值降低( p
＜0．05) 。ABO 血型COX－1 基因位点rs1330344 基因型的比较结果显示，差异均不具有统计学意义( p＞0．05) 。
结论: ABO 血型病人服用阿司匹林后抗血小板作用存在差异，其抗血小板作用在O 血型病人最显著，在AB 血型
病人中最差。且其抗血小板差异可能与COX－1 基因位点rs1330344 无关。

Objective: To compare the change of platelet function index in ABO blood group patients
treated with aspirin，explore the different antiplatelet effects of aspirin in ABO blood groups and
the difference of the genotype of rs1330344 in cyclo－oxygen－ase－1( cox－1) associated with aspirin resistance
among ABO blood groups．Methods: 80 patients with myocardial ischemia and carotid atherosclerosis，
needed oral aspirin，according to the ABO blood group，were divided into 4 groups ( n = 20) :
A blood group ( A group) ，B blood group ( group B) ，O blood group ( O group) and AB blood group
( group AB) respectively． Platelet function indexes including PLT，MPV and TEG－MA were monitored
and compared before ( T1) and after oral aspirin for a week ( T2) ． The genotype of rs1330344 in cox－
1 was detected by PCＲ． Ｒesults: Compared T2 with T1，we found obvious decreases in PLT，MPV
and TEG－MA in O group( P＜0．05) ． Patients in AB group exhibited highest TEG－MA before and after
taking medicine( P＜0．05) ． All the COX－1 genotype of rs1330344 exhibited no differences( P＞0．05) ．
Conclusion: The antiplatelet effects are different in ABO blood group patients after taking aspirin，
which shows the significant effects in patients with O blood group and the weakest effects in patients
with AB blood group． And the difference in antiplatelet effects may be independent of cox － 1 gene
locus rs1330344．

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