目的: 探讨原发性高血压合并冠心病病人血清同型半胱氨酸水平及冠状动脉狭窄程度的临床分析。
方法: 选取2015－01～ 2017－09 期间我院心内科原发性高血压病人102 例作为对照组，原发性高血压合并冠心病
病人98 例作为实验组，检测血清同型半胱氨酸(Hcy)、超敏C 反应蛋白( hs－CＲP)、低密度脂蛋白胆固醇(LDLC)，
根据冠状动脉造影结果比较冠状动脉狭窄程度与血清同型半胱氨酸、低密度脂蛋白胆固醇的关系。结果:
原发性高血压合并冠心病组与原发性高血压组相比，Hcy、hs－CＲP、LDL－C 水平明显增高，有统计学意义(P＜
0．05);高血压合并冠心病组单支病变组Hcy 17．36± 0．28μmol /L，双支病变组20．48± 0．21μmol /L，多支病变组
24．56±0．33μmol /L，血清同型半胱氨酸水平及低密度脂蛋白胆固醇水平与冠状动脉病变程度呈正相关。结论:
血清同型半胱氨酸(Hcy)、超敏C 反应蛋白(hs－CＲP)、低密度脂蛋白胆固醇(LDL－C)为原发性高血压合并冠心
病的相关危险因素，血清同型半胱氨酸(Hcy)水平及低密度脂蛋白胆固醇(LDL－C)水平与冠状动脉病变程度呈
正相关，降低血清同型半胱氨酸(Hcy)、低密度脂蛋白胆固醇(LDL－C)可预防冠心病的发生。

Objective:To investigate the serum homocysteine level in patients with primary hypertension
complicated with coronary heart disease and its relationship with the degree of coronary
stenosis．Methods:A total of 200 patients with primary hypertension from January 2015 to September
2017 were studied．These patients were divided into two groups according to coronary angiography:102
cases of simple hypertension and 98 cases of hypertension complicated with coronary heart disease．Serum
levels of homocysteine(Hcy)，hypersensitive C－reactive protein(hs－CＲP)and low density lipoprotein
cholesterol(LDL－C)were measured．The relationship between coronary lesions and serum homocysteine
and low density lipoprotein cholesterol were compared according to coronary angiography．Ｒesults:
The levels of Hcy，hs － CＲP and LDL － C in patients with primary hypertension complicated with
coronary heart disease were significantly higher than those with primary hypertension ( P ＜ 0．05 )．
Patients with hypertension complicated with coronary heart disease The single－vessel disease group had
Hcy 17．36±0．28μmol /L，double－vessel disease group 20．48±0．21μmol /L，multi－vessel disease group
24．56±0．33μmol /L，serum homocysteine level and LDL－C level and conorary Arterial disease were
positively correlated．Conclusion:Serum homocysteine(Hcy)，high－sensitivity C－reactive protein(hs－
CＲP)，and low density lipoprotein cholesterol( LDL－C) are the risk factors associated with coronary
heart disease in patients with primary hypertension．Serum homocysteine(Hcy) levels and low－density
lipoprotein cholesterol(LDL－C)levels and coronary artery disease was positively correlated，reduce serum
homocysteine(Hcy)and low density lipoprotein cholesterol(LDL－C)can prevent the occurrence of
coronary heart disease．

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