辅助化疗与新辅助化疗( neoadjuvant chemotherapy，NAC) 已成为治疗浸润性乳腺癌的重要手段之 一，化疗疗效更是临床医师关注的重点，而肿瘤细胞原发或继发多药耐药性( multidrug resistant，MDＲ) 是乳腺癌 治疗过程中有待攻克的难关。随着乳腺癌治疗研究的深入，乳腺癌耐药基因的表达逐渐进入临床医师的视野， 并且意识到其表达程度更是决定了化疗的疗效。笔者就乳腺癌各种耐药基因的表达程度与化疗疗效的关系做 一综述，以供临床参考。

Adjuvant chemotherapy and neoadjuvant chemotherapy ( Neoadjuvant chemotherapy， NAC) have become one of the most important methods in the treatment of invasive breast cancer． Primary or secondary multidrug resistance( multidrug resistant，MDＲ) of tumor cells is a difficult prob- lem in breast cancer treatment．With the development of breast cancer therapy，the expression of drug－ resistant genes has gradually entered the field of view of clinicians，and the degree of expression has de- cided the efficacy of chemotherapy．The author of the various breast cancer resistance The relationship between drug gene expression and chemotherapeutic efficacy was reviewed for clinical reference．

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