目的 对三阴性与非三阴性乳腺癌超声造影特征及定量参数的差异性进行研究。方法 研究对象选自2017年05月至2019年06月收治于本院的乳腺癌病例293例,将以上入选病例依据术后免疫组化结果分为三阴性乳腺癌组(TNBC,n=41例)与非三阴性乳腺癌组(非TNBC,n=252例),所有病例均行CEUS检查,对两组乳腺癌病例的超声造影特征及定量参数进行分析。结果 TNBC组病变最常见的超声造影表现为弥漫性高增强(36/41,87.81%),增强后边缘清晰(32/41,38.05%)、增强 后形态规整(24/41,58.54%)、灌注缺损比例大(30/41,73.17%)、增强后范围等大(35/41,85.37%)；两组定量参数指标中,TNBC组在肿块整体Peak值及灌注最强区Peak值、Sharpness值方面与非TNBC组比较差异有统计学意义(均P<0.05)。结论 三阴性与非三阴性乳腺癌超声造影增强特征及灌注参数之间存在差异,超声造影在一定程度上反映了TNBC的生物学特征。

Objective To study the differences in contrast characteristics and quantitative parameters of triple-negative and non-triple-negative breast cancer. Methods The study subjects were selected from 293 breast cancer cases admitted to our hospital from May 2017 to June 2019. The above selected cases were divided into two groups based on the results of postoperative immunohistochemistry. One was a triple-negative breast cancer group (TNBC, n = 41 cases), and the other was a non-triple-negative breast cancer group (non-TNBC, n = 252 cases), all cases were examined by CEUS, and the contrast-enhanced ultrasound characteristics and quantitative parameters of the two groups of breast cancer cases were analyzed. Results The most common contrast-enhanced ultrasound findings in the TNBC group were diffuse high enhancement (36/41, 87.81%), sharp edges after enhancement (32/41, 38.05%), regular morphology after enhancement (24/41, 58.54%), The ratio of perfusion defect is large (30/41, 73.17%), and the range after enhancement is the same (35/41, 85.37%). Among the two quantitative parameter indicators, the TNBC group has the overall Peak value of the mass, the Peak value, Sharpness, and Sharpness Compared with the non-TNBC group, the difference was statistically significant (all P <0.05). Conclusion There is a difference between the contrast enhancement features and perfusion parameters of triple-negative and non-triple-negative breast cancer. Contrast-enhanced ultrasound reflects the biological characteristics of TNBC to a certain extent.

内蒙古自治区自然科学基金(2016MS(LH)0814)