miRNA是一类小分子非编码RNA,参与机体的发育、器官功能调节、免疫、细胞增殖、凋亡及微生物致病等诸多生物学过程,国内外许多研究发现,miRNA可能对胃癌的早期诊断提供帮助,并有望改善胃癌患者的预后。本文对近年来miRNA在胃癌的作用机制、miRNA与胃癌相关微生物的关系、miRNA与胃癌的诊断、治疗等方面的研究做一综述。

Absrtact:MiRNA is a group of small molecule of non-coding RNA, involved in the development of the body, organ function regulation, immunity, cell proliferation, apoptosis and microbial disease and many biological processes, many studies at home and abroad found that miRNA may help the early diagnosis of stomach cancer, and is expected to improve the prognosis of patients with stomach cancer. In this paper, the mechanism of the action of miRNA in gastric cancer, the relationship between miRNA and gastric cancer-related microorganisms, the diagnosis and treatment of miRNA and stomach cancer in recent years are reviewed.