摘要：目的 探讨基于高分辨率磁共振成像的大脑中动脉斑块定量参数与老年脑梗死患者临床预后的相关性。方法 回顾性收集2017年1月2019年1月我院收治的老年脑梗死患者220例为观察组，同期收集至我院健康体检的患者220例为对照组，行颅内动脉高分辨率磁共振，测量大脑中动脉斑块相关参数，包括斑块个数、斑块总厚度、斑块总体积，并分析其与老年脑梗死患者临床预后的相关性。结果 与对照组比较，观察组斑块个数增加(2.75±0.82 vs. 0.92±0.45, P=0.000)；斑块总厚度增加(4.48±1.88 vs. 1.28±0.85 mm, P=0.000)；斑块总体积增加(32.37±8.71 vs. 12.88±4.811 mm3, P=0.000)。斑块个数、斑块总厚度、斑块总体积与NIHSS评分、脑梗死容积正相关，与FMA量表评分、Barthel评分负相关(P<0.05)。结论 基于高分辨率磁共振成像的大脑中动脉斑块定量参数与老年脑梗死患者临床预后相关，可以作为预测患者预后的指标。

Abstract: Objective To investigate the correlation between quantitative parameters of middle cerebral artery plaque based on high resolution magnetic resonance imaging and clinical prognosis of elderly patients with cerebral infarction. Methods From January 2017 to January 2019, 220 elderly patients with cerebral infarction admitted to our hospital were retrospectively collected. During the same period, 220 patients with physical examination were collected. High resolution magnetic resonance imaging of intracranial artery was performed to measure the related parameters of middle cerebral artery plaque, including the number of plaques, the total thickness of plaques, the total volume of plaques, and to analyze its correlation with the clinical prognosis of elderly patients with cerebral infarction. Results When compared with the control group, the number of plaques in the observation group increased (2.75±0.82 vs. 0.92±0.45, P=0.000); the total thickness of plaques increased (4.48±1.88 vs. 1.28±0.85 mm, P=0.000); and the total volume of plaques increased (32.37±8.71 vs. 12.88±4.811 mm3, P=0.000). The number, thickness and volume of plaques were positively correlated with NIHSS score and cerebral infarction volume, negatively correlated with FMA score and Barthel score (P<0.05). Conclusion The quantitative parameters of middle cerebral artery plaque based on high resolution magnetic resonance imaging are related to the clinical prognosis of elderly patients with cerebral infarction, and can be used as a prognostic indicator.