目的 探讨喘可治穴位注射对非急性发作期支气管哮喘患者的表观遗传学机制。方法 90例非急性发作期支气管哮喘患者随机分为观察组和对照组。对照组常规治疗，观察组加用喘可治足三里穴位注射。结果 经治疗后，观察组患者的ACT评分显著高于对照组，5-mC 和5-hmC水平显著低于对照组。观察组患者的IFN-γ水平显著高于对照组。结论 喘可治穴位注射能显著改善患者的哮喘控制症状和肺功能，推测可能与调控机体DNA甲基化和羟甲基化，调节免疫反应有关。

Objective To study the effect of Chuankezhi on non-acute bronchial asthma. Methods The levels of 5 m C and 5-hmC in peripheral blood of all patients were measured. The levels of IFN- γ, IL-4,IL-17, 5 MC and 5-hmC were compared. Results The levels of 5-mC, 5-hmC IL-4 and IL-17 in observation group were lower than control group. Conclusions Acupoint injection of Chuankezhi can be used for treating the bronchial asthma patients, can improve the lung function of the patients, and can be related to the regulation of the DNA methylation and the hydroxymethylation of the organism and the regulation of the immune response.

浦东新区卫生和计划生育委员会学科建设主攻课题，PWZzb2017-12