癫痫是脑神经元群异常放电而引起的肢体抽搐或非抽搐性发作的神经系统疾病 ^[1],且颞叶癫痫在成人的癫痫发作类型中最常见,常表现为脑内局灶起源并伴有意识障碍的精神运动性发作。目前,许多学者认为颞叶癫痫的致痫灶在海马,因为多数患者在切除海马后可使癫痫发作频率减少或消失^[2]。大量研究表明,海马的可塑性与颞叶癫痫有关,因此,多年来海马在颞叶癫痫发病机理研究中一直是最受重视也是研究最多的结构。现将海马结构的解剖和功能联系以及海马可塑性变化与颞叶癫痫的关系综述如下。

Epilepsy is a neurological disease caused by convulsive limbs or non-convulsive seizures caused by abnormal discharge of brain neuron groups [1], and temporal lobe epilepsy is the most common type of seizures in adults, often manifested as focal origin in the brain accompanied by Psychomotor seizures with disturbance of consciousness. At present, many scholars believe that the epileptogenic foci of temporal lobe epilepsy are in the hippocampus, because most patients can reduce or disappear the frequency of seizures after resection of the hippocampus [2]. A large number of studies have shown that the plasticity of the hippocampus is related to temporal lobe epilepsy. Therefore, the hippocampus has been the most valued and most studied structure in the study of the pathogenesis of temporal lobe epilepsy for many years. The anatomical and functional connections of hippocampal structure and the relationship between hippocampal plasticity changes and temporal lobe epilepsy are summarized below.

R741.02