目的: 观察并分析临床药师参与抗菌药物合理使用管理后的作用。方法: 采用回顾性研究方法,对比临床药师参与抗菌药物合理使用管理前(2018年1月-5月)与参与管理后(2018年6-12月)抗菌药物合理使用相关指标以及不合理医嘱的变化情况。结果：参与管理后住院患者抗菌药物使用强度(AUD)增长率较参与管理前下降了45.70%,住院患者抗菌药物使用率的增长率下降了13.39%,抗菌药物、限制级抗菌药物的微生物送检率的增长率分别增加了23.72 %和9.95%。参与管理前后的用药不合理医嘱发生率明显减少,其中遴选药品不适宜、给药疗程不合理的差异有统计学意义(P＜0.05),用法用量不合理、给药时机不合理的差异无统计学意义(P＜0.05)。结论:临床药师参与科室抗菌药物管理有助于抗菌药物合理使用相关指标及不合理用药情况的改善。

Objective To Observe and analyze the effect of clinical pharmacists in the management of rational use of antibiotics. Methods To compare the changes of relevant indicators and unreasonable orders of clinical pharmacist before participation in the management of rational use of antibiotics (January to May 2018) and after participation in the management (June to December 2018). Results After participation in the management, the growth rate of the antibiotic use intensity (AUD) of inpatients decreased by 45.70%, The growth rate of inpatient utilization decreased by 13.39%, The growth rates of microbial delivery of antimicrobial agents and restricted level antimicrobial agents increased by 23.72% and 9.95% respectively； The incidence of irrational medication orders decreased significantly before and after management, Among them, the difference between before and after intervention was statistically significant(P＜0.05),There was no statistic difference between the unreasonable dosage and time of administration(P＜0.05). Conclusion The participation of clinical pharmacist in the management of antimicrobial agents is helpful to the improvement of the indicators related to the rational use of antimicrobial agents and the irrational use of drugs.

内蒙古自治区人民医院博士科研启动基金(2019BS03)；内蒙古自治区自然科学(2019MS08078)