[摘要] 目的 探讨甲状腺癌相关参数与疾病进展的关系，并分析其疗效评估效能。方法 选取2016年12月～2019年10月我院甲状腺癌患者83例为研究对象，患者均行超声造影（CEUS）及甲状腺手术治疗，分析甲状腺超声相关参数[峰值强度（PI）、达峰时间（TTP）、平均通过时间（MTT）、曲线下面积（AUC）]与甲状腺癌疾病进展（临床分期）及术后疗效的诊断价值。结果 四组血清PI、AUC、TTP、MTT值比较差异有统计学意义（P<0.05），且PI、AUC、TTP、MTT参数值Ⅰ期<Ⅱ期<Ⅲ期<Ⅳ期，组间差异具有统计学意义（P＜0.05）。83例甲状腺癌患者中，经完全腔镜甲状腺手术治疗，淋巴结转移患者32例（38.55%），未发生转移者51例（61.45%），且淋巴结转移患者的PI、AUC、TTP、MTT均低于无淋巴结转移者，差异具有统计学意义（P＜0.05）。ROC曲线分析显示，TTP、PI、AUC、MTT诊断甲状腺癌患者疗效的AUC为0.863、0.898、0.821、0.764，均具有一定准确性，但联合诊断价值更高（AUC=0.919，敏感度、特异度为81.3%、94.1%）。结论 随临床分期程度的加深，CEUS相关参数值不断降低，且CEUS检查对甲状腺癌疗效评估价值较高，利于甲状腺癌患者的早期治疗。

[Abstract] Objective To investigate the relationship between thyroid cancer-related parameters and disease progression, and to analyze the efficacy evaluation. Methods Selection in December 2016 ~ October 2019 from 83 patients with thyroid cancer as the research object, the patients were lines of contrast-enhanced ultrasound (CEUS) and thyroid surgery, thyroid ultrasonic analysis related parameters [peak intensity (PI), tmax (TTP), average (determined by MTT) through time, the area under the curve (AUC)] and thyroid cancer disease progression (clinical stage) and postoperative effect of diagnostic value. Results There were statistically significant differences in serum PI, AUC, TTP and MTT between the four groups (P<0.05), and PI, AUC, TTP, determined by MTT parameter values Ⅰ period & lt;Ⅱ period & lt;Ⅲ period & lt;Ⅳ stage, the difference between groups with statistical significance (P < 0.05).Among the 83 patients with thyroid cancer, 32 (38.55%) had lymph node metastasis and 51 (61.45%) had no lymph node metastasis, and the PI, AUC, TTP and MTT of the patients with lymph node metastasis were lower than those without lymph node metastasis, with statistically significant difference (P < 0.05).ROC curve analysis showed that THE AUC of TTP, PI, AUC and MTT in the diagnosis of thyroid cancer patients was 0.863, 0.898, 0.821 and 0.764, all of which had certain accuracy, but the combined diagnostic value was higher (AUC=0.919, sensitivity and specificity were 81.3% and 94.1%) .Conclusion With the deepening of clinical stage, the values of CEUS related parameters were continuously reduced, and the evaluation value of CEUS examination on the efficacy of thyroid cancer was relatively high, which was conducive to the early treatment of thyroid cancer patients.