目的 探讨血清胃蛋白酶原含量检测对胃溃疡患者诊断价值。方法 选取我院2018年9月-2019年9月我院收治的确诊胃溃疡患者60例作为观察组，并选取同期我院体检健康志愿者60例作为健康组，采用ELISA法分别对两组患者血清胃蛋白酶原Ⅰ（PGⅠ）、血清胃蛋白酶原Ⅱ（PGⅡ）含量进行检测，比较两组血清胃蛋白酶原水平。结果 观察组血清胃蛋白酶原PGⅠ（161.42±18.27）、PGⅡ（22.42±3.14）水平明显高于健康组（102.24±13.38、9.94±1.23），差异有统计学意义（t=20.243、28.665，P=0.000）。结论 血清胃蛋白酶原含量在胃溃疡患者和健康人群中存在明显差异，具有较高诊断价值，值得临床进一步推广使用。

Objective Explore the diagnostic value of serum pepsinogen in patients with gastric ulcer.Methods 60 patients with gastric ulcer admitted to our hospital from September 2018 to September 2019 were selected as the observation group, and 60 healthy volunteers were selected as the control group at the same time. The serum pepsinogen Ⅰ (PG Ⅰ) and serum pepsinogen Ⅱ (PG Ⅱ) contents of the two groups were detected by ELISA, and the serum pepsinogen levels of the two groups were compared.Results The levels of serum pepsinogen PG Ⅰ (161.42 ± 18.27) and PG Ⅱ (22.42 ± 3.14) in the observation group were significantly higher than those in the healthy group (102.24 ± 13.38, 9.94 ± 1.23), and the difference was statistically significant (t = 20.243, 28.665, P = 0.000).Conclusion The content of serum pepsinogen in patients with gastric ulcer and healthy people is significantly different, which has a high diagnostic value and is worthy of further clinical application.