丙戊酸钠是一种临床广泛使用的抗癫痫药物，用于癫痫患者的全身性和部分性发作。然而，其不良反应多，如高血氨症、肝毒性、内分泌紊乱等。对于接受大剂量或长期使用丙戊酸钠治疗的患者来说，高血氨症最为常见，其可引起中枢神经系统损害，包括严重的高血氨脑病。这样势必会影响丙戊酸钠的临床应用。本文通过对1例丙戊酸钠治疗癫痫持续状态引起高血氨脑病的病例进行分析及合理干预，希望为临床合理使用抗癫痫药物提供一定的参考，避免不良反应的发生，提高药物治疗效果。

Sodium valproate is a widely used anti-epileptic drug for generalized and partial seizures in patients with epilepsy. However, there are many adverse reactions, such as hyperammonemia, liver toxicity, endocrine disorders and so on. For patients receiving high-dose or long-term use of sodium valproate treatment, hyperammonemia is the most common, which can cause central nervous system damage, including severe hyperammonemic encephalopathy. This is bound to affect the clinical application of sodium valproate. This article analyzes and rationally intervenes a case of high blood ammonia encephalopathy caused by sodium valproate in the treatment of status epilepticus, hoping to provide a certain reference for the rational use of antiepileptic drugs in clinical practice, avoid adverse reactions and improve the effect of drug treatment.