骨巨细胞瘤（Giant Cell tumor of Bone，GCTB）一般被认为是交界性肿瘤，部分患者表现出一定的恶性倾向。GCTB的发病机制尚未明确，手术切除是其主要治疗方法，但对于术后复发或无法进行手术切除的患者仍没有标准的治疗方案。RANK信号通路是骨重建的关键通路，已被明确发现其参与GCTB的发生和发展。本文综述了RANK通路在GCTB发生发展和治疗中的作用，为其临床诊断和治疗提供帮助。

Giant cell tumor of bone (Giant Cell tumor of Bone,GCTB) is generally regarded as a borderline tumor, and some patients show a certain malignant tendency. The pathogenesis of GCTB is not clear, and surgical resection is the main treatment, but there is still no standard treatment for patients with postoperative recurrence or unable to undergo surgical resection. RANK signal pathway is the key pathway of bone remodeling, and it has been clearly found that it is involved in the occurrence and development of GCTB. This article reviews the role of RANK pathway in the occurrence, development and treatment of GCTB, and provides help for its clinical diagnosis and treatment.

国家自然科学基金项目（ OPG/RANK/RANKL在骨巨细胞瘤中作用及MicroRNA-210对其调控的实验研究）