摘要:目的 探讨P53、P16和Ki67在卵巢上皮性癌中的表达及其与临床病理特征的关系。方法 收集2016年1月到2018年12月内蒙古医科大学第一附属医院20例卵巢良性肿瘤组织和60例卵巢上皮性癌组织标本，应用免疫组织化学法检测其中P53、P16和Ki67的表达情况；对60例上皮性卵巢癌患者的临床数据进行回顾分析。结果 P53、P16和Ki67在卵巢上皮性癌组织中的表达水平远远高于卵巢良性肿瘤组织中的表达水平(P<0.05)。P53、P16和Ki67的表达水平与卵巢上皮性癌患者年龄、组织类型、组织分级和FIGO分期明显相关。P53突变、P16与Ki67高表达三者相互之间均有显著相关性，成正相关（P<0.05）。经计算P53、P16和Ki67三项联合诊断灵敏度最高。结论 卵巢上皮性癌发生恶变的过程中与P53、P16以及Ki67的表达异常有关，且与卵巢上皮性癌组织类型有关，可能作为诊断和预后的特异性抗体指标。

Abstact：Objective To investigate the expression of P53、P16 and Ki67 in ovarian epithelial carcinoma and its relationship with clinicopathological features. Methods From January 2016 to December 2018,20 cases of benign ovarian tumor and 60 cases of ovarian epithelial carcinoma were collected from the first affiliated hospital of Inner Mongolia Medical University, and the expression of P53、P16 and Ki67 was detected by immunohistochemistry. The clinical data of 60 cases of epithelial ovarian cancer were retrospectively analyzed. Results The expression level of P53、P16 and Ki67 in ovarian epithelial carcinoma tissue is much higher than that in ovarian benign tumor tissue (P<0.05). the expression levels of P53、P16 and Ki67 were significantly associated with age of patients, tissue type, tissue grade, and FIGO stage in patients with ovarian epithelial carcinoma. P53 mutation, P16 and high expression of Ki67 were significantly correlated with each other, and were positively correlated (P<0.05).The combined diagnostic sensitivity of P53, P16 and Ki67 was calculated to be the highest. Conclusion The malignant transformation of ovarian epithelial carcinoma is related to the abnormal expression of P53、P16 and Ki67, and to the tissue type of ovarian epithelial carcinoma, which may be used as a specific antibody index for diagnosis and prognosis.