乳腺癌的治疗以手术切除为主，且手术切除范围逐渐缩小，目前，病灶或患侧乳房切除加前哨淋巴结活检术是临床腋窝淋巴结阴性的早期乳腺癌的标准术式。前哨淋巴结活检术的关键在于示踪方法的选择，自前哨淋巴结的概念提出以来，示踪方法一直都是国内外学者的研究热点，到目前，示踪方法主要包括：染料法、核素法、蓝色染料与核素联合的双示踪法、超顺磁性氧化铁示踪法等。本文综述了上述各示踪方法的优缺点及临床应用价值。

The treatment of breast cancer is mainly surgical resection, and the scope of surgical resection has been gradually reduced. At present, focus or affected side mastectomy plus Sentinel lymph node biopsy is the standard procedure for clinical axillary lymph node negative early breast cancer. The key of Sentinel lymph node biopsy is the choice of tracing method. Since the concept of Sentinel lymph node was put forward, tracing method has been a hot spot of domestic and foreign scholars, the tracer methods mainly include: Dye method, nuclide method, Blue Dye and nuclide combined double tracer method, superparamagnetic iron oxide tracer method and so on. This article reviews the advantages and disadvantages of the above-mentioned tracer methods and their clinical value.