[摘要] 目的 观察良性癫痫伴中央颞区棘波（BECT）变异型患儿的临床特征，分析BECT变异型发生的影响因素，为未来儿童BECT变异型的预防干预提供指导。方法 回顾性分析，采集2017年1月-2019年12月我院25例BECT变异型患儿临床资料，将其纳入A组，同期25例典型BECT患儿病历临床资料，将其纳入B组，观察并比较两组患儿主要表现，找出儿童BECT变异型的典型特征，比较A组与B组患儿的基线资料，经单因素与多因素检验，分析儿童BECT变异型发病的影响因素。结果 本研究25例BECT变异型患儿临床特征包括不典型失神、负性肌痉挛、口咽部运动障碍、认知功能下降，其中不典型失神是其主要临床特征；经单因素与多因素Logistic回归分析结果显示，脑电图恶化、睡眠期癫痫性电持续状态、脑解剖结构异常、微量元素异常是儿童BECT变异型发病的影响因素（OR＞1，P＜0.05），且以脑电图恶化带来的影响最大，可能是BECT变异型发病的独立危险因素。结论 BECT变异型发病的原因可能与患儿脑电图恶化、睡眠期癫痫性电持续状态、脑解剖结构异常、微量元素异常有关，尤以脑电图恶化影响显著，应引起临床重视

[Abstract] Objective To observe the clinical features of variants of benign childhood epilepsy with central-temporal spikes (BECT), to analyze the influencing factors of variants of BECT, and to provide guidance for the preventive intervention of variants of BECT in the future. Methods The retrospective analysis was performed, the clinical data of 25 children with variants of BECT, and they were collected and included in control group. The medical data of 25 typical BECT during the same period were included in B group. The main performance of the two groups of children was observed and compared, the typical features of children with variants of BECT were found, and the baseline data of children in A group and B group were compared. The single-factor and multi-factor tests were used to analyze the influencing factors of children with variants of BECT. Results The clinical features of 25 children with variants of BECT in this study included atypical absence, negative myospasm, oropharyngeal dyskinesia, and decline in cognitive function, and atypical absence was the main clinical feature; Univariate and multivariate Logistic regression analysis showed that electroencephalogram deterioration, electrical status epilepticus in sleep stage, abnormal brain anatomy structure, and abnormal trace elements were the influencing factors of the incidence of variants of BECT in children (OR>1, P<0.05), and the effect of electroencephalogram deterioration was the greatest, which may be the independent risk factor for the onset of variants of BECT. Conclusion The causes of variants of BECT may be related to the electroencephalogram deterioration, electrical status epilepticus in sleep stage, abnormal brain anatomy structure, and abnormal trace elements, and the effect of electroencephalogram deterioration is particularly significant and should arouse clinical attention.