[关键词]
[摘要]
目的:探讨蒙药哈它各其-7散对压疮大鼠相关炎性因子IL-1、IL-6及hs-CRP含量的影响。方法:将大鼠随机分为4个组,分别为假手术组,模型组,哈它各其-7组和云南白药组。除假手术组外,其余各组造模成功后,连续14于创面处经皮给药,分别在给药后第1、3、7、14天测量创面面积。末次给药后取创面皮肤组织进行HE染色,并采取腹主动脉血测量其IL-1、IL-6、hs-CRP含量。结果:与模型组比较,哈它各其-7组显著缩小创面面积,并降低压疮大鼠血清中的IL-1、IL-6、hs-CRP水平。结论:蒙药哈它各其散能促进压疮创面的愈合,这可能与抗炎作用相关。
[Key word]
[Abstract]
Objective: To investigate the influence of Mongolian medicine Hatageqi-7 powder on related inflammatory factors in rats with pressure ulcers. Methods: 32 rats were divided into 4 groups randomly; sham operation group, model group, hatageqi-7 group and Yunnan Baiyao group. Except for the sham operation group, the other groups were given percutaneous administration to the wound for 14 consecutive days after successful modeling, and the wound area was measured on the 1, 3, 7, and 14 days after administration. After the last administration, take the wound skin tissue for HE staining, and take the abdominal aortic blood to measure its IL-1, IL-6, hs-CRP content. Results: Compared with the model group, the Hatageqi-7 group significantly reduced the wound area and reduced the levels of IL-1, IL-6, and hs-CRP in the serum of pressure ulcer rats. Conclusion: Hatageqi-7 can promote the healing of pressure ulcer ,which may be relevant with anti-inflammatory effects.
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[基金项目]
内蒙古自治区自然科学基金课题(2018MS08013);内蒙古医科大学科技百万工程项目(YKD2017KJBW001);内蒙古医科大学协同创新项目(MYYXT202909);内蒙古医科大学博士启动资金项目(YKD2018BSJJ004)