[关键词]
[摘要]
脑的功能磁共振( functional magnetic resonance imaging,fMRI)是利用磁共振成像生成反映脑血流变化的图像。它主要以实时无辐射的探测技术对特定的大脑皮层区域进行扫描,以此来观察大脑神经网络情况。血氧水平依赖功能磁共振(blood oxygen level dependent functional magnetic resonance imaging,bold-fMRI)主要是神经元活动引起血液动力的改变,是目前功能磁共振在临床研究方面应用广泛的一个技术。当大脑神经活跃时,其附近的血流及血流耗氧增加,顺磁性的去氧血红蛋白浓度的变化引起横向磁化豫缩短效应,也就是T2加权像信号,T2加权像信号的强弱间接反映局部脑神经活跃的情况。通过功能连接和弥散张量成像(diffusion tensor imaging,DTI)技术计算统计出哪些脑区在执行人的语言功能,进而针对这些脑区进行蒙医针灸和重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)两种治疗,来促进脑卒中后患者语言功能的恢复,血氧水平依赖功能磁共振则给临床治疗提供可靠的影像依据。
[Key word]
[Abstract]
Functional magnetic resonance imaging (fMRI) of brain is to use magnetic resonance imaging to generate images reflecting changes of cerebral blood flow. It mainly uses real-time non-radiation detection technology to scan specific cerebral cortex areas, so as to observe the situation of brain neural network. Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (bold-fMRI) is a widely used technology in clinical research, which mainly changes the dynamics caused by neuron activity. When the brain nerve is active, the oxygen consumption of blood flow and blood flow near it increases, and the change of para-magnetic deoxy hemoglobin concentration causes the transverse magnetization relaxation shortening effect, that is, T2 weighted image signal, which indirectly reflects the local brain nerve activity. The functional connection and diffusion tensor imaging (DTI) technology are used to calculate and count which brain regions are performing human language function, and then Mongolian medicine acupuncture and repetitive trans-cranial magnetic stimulation (rTMS) are used for these brain regions to promote the recovery of language function of patients after stroke. The blood oxygen level-dependent functional magnetic resonance imaging provides reliable imaging basis for clinical treatment.
[中图分类号]
R811.5 ;R493
[基金项目]