目的：研究小青龙汤联合中药热奄包对喘息性支气管炎患儿白介素-4(interleukin-4, IL-4)、白介素-13(interleukin-13, IL-13)、干扰素-γ(interferon-γ, IFN-γ)水平的影响。方法：选取60例喘息性支气管炎寒性哮喘患儿按随机数字表法分为对照组与观察组,每组各30例。对照组按西医常规对症治疗,治疗组在西医常规治疗的基础上加用小青龙汤联合中药热奄包,比较两组患儿临床疗效、治疗前后血清IL-4、IL-13、IFN-γ水平。结果：两组临床疗效比较,治疗组有效率高于对照组,差异有统计学意义(P<0.05)。治疗后的治疗组患儿血清IL-4、IL-13水平低于对照组,差异有统计学意义(P<0.05)；治疗后治疗组患儿血清IFN-γ水平高于对照组,差异有统计学意义(P<0.05)。结论:小青龙汤联合热奄包可降低IL-4、IL-13并升高IFN-γ水平,纠正Th1/ Th2细胞因子的失调,减轻气道炎症,缓解气道高反应性,有效治疗喘息性支气管炎。

ABSTRACT Objective: To study the effect of Xiao Qinglong Tang combined with Chinese medication hot compress on the levels of interleukin-4(IL-4), interleukin-13(IL-13), interferon-γ(IFN-γ) in children with asthmatic bronchitis. Methods:60 children with asthmatic bronchitis and cold asthma were divided into control group and observation group according to the random number table method, each group 30 cases. The control group was treated with western medicine routine, and the treatment group was treated with Xiao Qinglong Tang combined with Chinese medication hot compress to compare the clinical efficacy of the two groups before and after treatment, serum interleukin-4(IL-4), interleukin-13(IL-13), interferon-γ(IFN--γ) levels. Results: Compared with the two groups, the effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P<0.05). The blood IL-4、IL-13 level of the children in the treatment group after treatment was lower than that in the control group, and the difference was statistically significant (P<0.05); the serum IFN-γ level of the children in the treatment group after treatment was higher than that in the control group (P<0.05). Conclusion: Xiao Qinglong Tang combined with Chinese medication hot compress can reduce IL-4、IL-13 and increase IFN-γ level, correct the imbalance of Th1/Th2 cytokines, reduce airway inflammation, relieve airway hyperresponsiveness, and effectively treat asthmatic bronchitis.