目的 分析厦门市2014－2018年围产儿唇腭裂流行状况及流行病学特征。方法 采用以医院为基础的监测方案,收集唇腭裂患儿资料。结果 共纳入围产儿421 457例,报告围产儿唇腭裂297例,其中单纯腭裂98例,单纯唇裂92例,唇裂合并腭裂107例,总唇裂发生率7.05/万。单纯唇裂、唇裂合并腭裂及非综合征性唇腭裂监测发生率男性高于女性,单纯腭裂女性高于男性；总唇裂及各分类城镇均高于乡村,但无明显年龄分布特征。另监测报告28周以内胎儿唇腭裂184例,其中唇裂合并腭裂166例,28周以内胎儿唇腭裂在性别分布、分类构成、诊断时间及诊断方式分布方面与围产儿相比均显著不同。2014-2018年,厦门市围产儿唇腭裂监测发生率稳定,未呈现上升或下降趋势。结论 围产儿唇腭裂监测频率是患病率,而不是发病率。2014-2018年,厦门市围产儿唇腭裂患病率处于相对较低水平,并保持稳定。超声检查是产前诊断唇腭裂唯一有效的手段,普及超声检查并提高超声检查人员的诊断水平是控制围产儿唇腭裂患病率的有效干预措施。

Objective To determine the prevalence and characteristics of cleft lip(CL) and/or cleft palate(CP) among perinatal infants in Xiamen during 2014-2018. Methods The birth defect surveillance was based on hospital .The data of cleft lip and palate reported by all maternity hospitals in Xiamen during 2014-2018 were analyzed. Results 297 infants with a cleft defect were found among 421457 perinatal infants in time period 2014-2018 including 98 CL withou CP, 92 CP without CL and 102 CP with CL. The overall prevalence was 7.05 per 10 000 births. No traceable trend was found in the prevalence. The prevalence of CL without CP, CL with CP was higher among male perinatal infants, while CP without CL was higher among female. The prevalence of CL and/or CP were all higher in urban regions. No significant difference was observed among the age groupings.184 cases fetuses of gestational weeks <28 with a cleft defect were found. The distributions of gender, classification, diagnosis method were significant different between perinatal infants and fetuses of gestational weeks <28.Conclusions The surveillance rates of CP and/or CL were birth prevalence but not incidence. The CP and/or CL prevalence of Xiamen was at a lower level. The examination of fetal lip and palate in mid- gestation by ultrasonography was the only feasible diagnosis method at present. To popularize ultrasonography and improve skills among ultrasound doctors was the effective intervention measure.